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Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp
Separacenes A–D (1–4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1–4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher’s method. Separacenes A–B (1–2), which share...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766871/ https://www.ncbi.nlm.nih.gov/pubmed/23945600 http://dx.doi.org/10.3390/md11082882 |
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author | Bae, Munhyung Kim, Heegyu Shin, Yoonho Kim, Byung Yong Lee, Sang Kook Oh, Ki-Bong Shin, Jongheon Oh, Dong-Chan |
author_facet | Bae, Munhyung Kim, Heegyu Shin, Yoonho Kim, Byung Yong Lee, Sang Kook Oh, Ki-Bong Shin, Jongheon Oh, Dong-Chan |
author_sort | Bae, Munhyung |
collection | PubMed |
description | Separacenes A–D (1–4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1–4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher’s method. Separacenes A–B (1–2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C–D (3–4) possess a triene moiety between two diol substructures. Separacenes A–D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549. |
format | Online Article Text |
id | pubmed-3766871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37668712013-09-09 Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp Bae, Munhyung Kim, Heegyu Shin, Yoonho Kim, Byung Yong Lee, Sang Kook Oh, Ki-Bong Shin, Jongheon Oh, Dong-Chan Mar Drugs Article Separacenes A–D (1–4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1–4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher’s method. Separacenes A–B (1–2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C–D (3–4) possess a triene moiety between two diol substructures. Separacenes A–D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549. MDPI 2013-08-13 /pmc/articles/PMC3766871/ /pubmed/23945600 http://dx.doi.org/10.3390/md11082882 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Bae, Munhyung Kim, Heegyu Shin, Yoonho Kim, Byung Yong Lee, Sang Kook Oh, Ki-Bong Shin, Jongheon Oh, Dong-Chan Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp |
title | Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp |
title_full | Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp |
title_fullStr | Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp |
title_full_unstemmed | Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp |
title_short | Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp |
title_sort | separacenes a–d, novel polyene polyols from the marine actinomycete, streptomyces sp |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766871/ https://www.ncbi.nlm.nih.gov/pubmed/23945600 http://dx.doi.org/10.3390/md11082882 |
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