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The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells

Fucoidan, a sulfated polysaccharide, has a variety of biological activities, such as anti-cancer, anti-angiogenic and anti-inflammatory. However, the mechanisms of action of fucoidan as an anti-cancer agent have not been fully elucidated. The present study examined the anti-cancer effect of fucoidan...

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Autores principales: Boo, Hye-Jin, Hong, Ji-Young, Kim, Sang-Cheol, Kang, Jung-Il, Kim, Min-Kyoung, Kim, Eun-Ji, Hyun, Jin-Won, Koh, Young-Sang, Yoo, Eun-Sook, Kwon, Jung-Mi, Kang, Hee-Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766877/
https://www.ncbi.nlm.nih.gov/pubmed/23966032
http://dx.doi.org/10.3390/md11082982
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author Boo, Hye-Jin
Hong, Ji-Young
Kim, Sang-Cheol
Kang, Jung-Il
Kim, Min-Kyoung
Kim, Eun-Ji
Hyun, Jin-Won
Koh, Young-Sang
Yoo, Eun-Sook
Kwon, Jung-Mi
Kang, Hee-Kyoung
author_facet Boo, Hye-Jin
Hong, Ji-Young
Kim, Sang-Cheol
Kang, Jung-Il
Kim, Min-Kyoung
Kim, Eun-Ji
Hyun, Jin-Won
Koh, Young-Sang
Yoo, Eun-Sook
Kwon, Jung-Mi
Kang, Hee-Kyoung
author_sort Boo, Hye-Jin
collection PubMed
description Fucoidan, a sulfated polysaccharide, has a variety of biological activities, such as anti-cancer, anti-angiogenic and anti-inflammatory. However, the mechanisms of action of fucoidan as an anti-cancer agent have not been fully elucidated. The present study examined the anti-cancer effect of fucoidan obtained from Undaria pinnatifida in PC-3 cells, human prostate cancer cells. Fucoidan induced the apoptosis of PC-3 cells by activating both intrinsic and extrinsic pathways. The induction of apoptosis was accompanied by the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) and the inactivation of p38 MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt. In addition, fucoidan also induced the up-regulation of p21(Cip1/Waf) and down-regulation of E2F-1 cell-cycle-related proteins. Furthermore, in the Wnt/β-catenin pathway, fucoidan activated GSK-3β that resulted in the decrease of β-catenin level, followed by the decrease of c-myc and cyclin D1 expressions, target genes of β-catenin in PC-3 cells. These results suggested that fucoidan treatment could induce intrinsic and extrinsic apoptosis pathways via the activation of ERK1/2 MAPK, the inactivation of p38 MAPK and PI3K/Akt signaling pathway, and the down-regulation of Wnt/β-catenin signaling pathway in PC-3 prostate cancer cells. These data support that fucoidan might have potential for the treatment of prostate cancer.
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spelling pubmed-37668772013-09-09 The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells Boo, Hye-Jin Hong, Ji-Young Kim, Sang-Cheol Kang, Jung-Il Kim, Min-Kyoung Kim, Eun-Ji Hyun, Jin-Won Koh, Young-Sang Yoo, Eun-Sook Kwon, Jung-Mi Kang, Hee-Kyoung Mar Drugs Article Fucoidan, a sulfated polysaccharide, has a variety of biological activities, such as anti-cancer, anti-angiogenic and anti-inflammatory. However, the mechanisms of action of fucoidan as an anti-cancer agent have not been fully elucidated. The present study examined the anti-cancer effect of fucoidan obtained from Undaria pinnatifida in PC-3 cells, human prostate cancer cells. Fucoidan induced the apoptosis of PC-3 cells by activating both intrinsic and extrinsic pathways. The induction of apoptosis was accompanied by the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) and the inactivation of p38 MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt. In addition, fucoidan also induced the up-regulation of p21(Cip1/Waf) and down-regulation of E2F-1 cell-cycle-related proteins. Furthermore, in the Wnt/β-catenin pathway, fucoidan activated GSK-3β that resulted in the decrease of β-catenin level, followed by the decrease of c-myc and cyclin D1 expressions, target genes of β-catenin in PC-3 cells. These results suggested that fucoidan treatment could induce intrinsic and extrinsic apoptosis pathways via the activation of ERK1/2 MAPK, the inactivation of p38 MAPK and PI3K/Akt signaling pathway, and the down-regulation of Wnt/β-catenin signaling pathway in PC-3 prostate cancer cells. These data support that fucoidan might have potential for the treatment of prostate cancer. MDPI 2013-08-19 /pmc/articles/PMC3766877/ /pubmed/23966032 http://dx.doi.org/10.3390/md11082982 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Boo, Hye-Jin
Hong, Ji-Young
Kim, Sang-Cheol
Kang, Jung-Il
Kim, Min-Kyoung
Kim, Eun-Ji
Hyun, Jin-Won
Koh, Young-Sang
Yoo, Eun-Sook
Kwon, Jung-Mi
Kang, Hee-Kyoung
The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells
title The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells
title_full The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells
title_fullStr The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells
title_full_unstemmed The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells
title_short The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells
title_sort anticancer effect of fucoidan in pc-3 prostate cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766877/
https://www.ncbi.nlm.nih.gov/pubmed/23966032
http://dx.doi.org/10.3390/md11082982
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