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The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells
Fucoidan, a sulfated polysaccharide, has a variety of biological activities, such as anti-cancer, anti-angiogenic and anti-inflammatory. However, the mechanisms of action of fucoidan as an anti-cancer agent have not been fully elucidated. The present study examined the anti-cancer effect of fucoidan...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766877/ https://www.ncbi.nlm.nih.gov/pubmed/23966032 http://dx.doi.org/10.3390/md11082982 |
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author | Boo, Hye-Jin Hong, Ji-Young Kim, Sang-Cheol Kang, Jung-Il Kim, Min-Kyoung Kim, Eun-Ji Hyun, Jin-Won Koh, Young-Sang Yoo, Eun-Sook Kwon, Jung-Mi Kang, Hee-Kyoung |
author_facet | Boo, Hye-Jin Hong, Ji-Young Kim, Sang-Cheol Kang, Jung-Il Kim, Min-Kyoung Kim, Eun-Ji Hyun, Jin-Won Koh, Young-Sang Yoo, Eun-Sook Kwon, Jung-Mi Kang, Hee-Kyoung |
author_sort | Boo, Hye-Jin |
collection | PubMed |
description | Fucoidan, a sulfated polysaccharide, has a variety of biological activities, such as anti-cancer, anti-angiogenic and anti-inflammatory. However, the mechanisms of action of fucoidan as an anti-cancer agent have not been fully elucidated. The present study examined the anti-cancer effect of fucoidan obtained from Undaria pinnatifida in PC-3 cells, human prostate cancer cells. Fucoidan induced the apoptosis of PC-3 cells by activating both intrinsic and extrinsic pathways. The induction of apoptosis was accompanied by the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) and the inactivation of p38 MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt. In addition, fucoidan also induced the up-regulation of p21(Cip1/Waf) and down-regulation of E2F-1 cell-cycle-related proteins. Furthermore, in the Wnt/β-catenin pathway, fucoidan activated GSK-3β that resulted in the decrease of β-catenin level, followed by the decrease of c-myc and cyclin D1 expressions, target genes of β-catenin in PC-3 cells. These results suggested that fucoidan treatment could induce intrinsic and extrinsic apoptosis pathways via the activation of ERK1/2 MAPK, the inactivation of p38 MAPK and PI3K/Akt signaling pathway, and the down-regulation of Wnt/β-catenin signaling pathway in PC-3 prostate cancer cells. These data support that fucoidan might have potential for the treatment of prostate cancer. |
format | Online Article Text |
id | pubmed-3766877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37668772013-09-09 The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells Boo, Hye-Jin Hong, Ji-Young Kim, Sang-Cheol Kang, Jung-Il Kim, Min-Kyoung Kim, Eun-Ji Hyun, Jin-Won Koh, Young-Sang Yoo, Eun-Sook Kwon, Jung-Mi Kang, Hee-Kyoung Mar Drugs Article Fucoidan, a sulfated polysaccharide, has a variety of biological activities, such as anti-cancer, anti-angiogenic and anti-inflammatory. However, the mechanisms of action of fucoidan as an anti-cancer agent have not been fully elucidated. The present study examined the anti-cancer effect of fucoidan obtained from Undaria pinnatifida in PC-3 cells, human prostate cancer cells. Fucoidan induced the apoptosis of PC-3 cells by activating both intrinsic and extrinsic pathways. The induction of apoptosis was accompanied by the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) and the inactivation of p38 MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt. In addition, fucoidan also induced the up-regulation of p21(Cip1/Waf) and down-regulation of E2F-1 cell-cycle-related proteins. Furthermore, in the Wnt/β-catenin pathway, fucoidan activated GSK-3β that resulted in the decrease of β-catenin level, followed by the decrease of c-myc and cyclin D1 expressions, target genes of β-catenin in PC-3 cells. These results suggested that fucoidan treatment could induce intrinsic and extrinsic apoptosis pathways via the activation of ERK1/2 MAPK, the inactivation of p38 MAPK and PI3K/Akt signaling pathway, and the down-regulation of Wnt/β-catenin signaling pathway in PC-3 prostate cancer cells. These data support that fucoidan might have potential for the treatment of prostate cancer. MDPI 2013-08-19 /pmc/articles/PMC3766877/ /pubmed/23966032 http://dx.doi.org/10.3390/md11082982 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Boo, Hye-Jin Hong, Ji-Young Kim, Sang-Cheol Kang, Jung-Il Kim, Min-Kyoung Kim, Eun-Ji Hyun, Jin-Won Koh, Young-Sang Yoo, Eun-Sook Kwon, Jung-Mi Kang, Hee-Kyoung The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
title | The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
title_full | The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
title_fullStr | The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
title_full_unstemmed | The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
title_short | The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
title_sort | anticancer effect of fucoidan in pc-3 prostate cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766877/ https://www.ncbi.nlm.nih.gov/pubmed/23966032 http://dx.doi.org/10.3390/md11082982 |
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