Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44

Five new anthranilic acid derivatives, penipacids A–E (1–5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive...

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Autores principales: Li, Chun-Shun, Li, Xiao-Ming, Gao, Shu-Shan, Lu, Yan-Hua, Wang, Bin-Gui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766882/
https://www.ncbi.nlm.nih.gov/pubmed/23966037
http://dx.doi.org/10.3390/md11083068
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author Li, Chun-Shun
Li, Xiao-Ming
Gao, Shu-Shan
Lu, Yan-Hua
Wang, Bin-Gui
author_facet Li, Chun-Shun
Li, Xiao-Ming
Gao, Shu-Shan
Lu, Yan-Hua
Wang, Bin-Gui
author_sort Li, Chun-Shun
collection PubMed
description Five new anthranilic acid derivatives, penipacids A–E (1–5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.
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spelling pubmed-37668822013-09-09 Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44 Li, Chun-Shun Li, Xiao-Ming Gao, Shu-Shan Lu, Yan-Hua Wang, Bin-Gui Mar Drugs Article Five new anthranilic acid derivatives, penipacids A–E (1–5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line. MDPI 2013-08-21 /pmc/articles/PMC3766882/ /pubmed/23966037 http://dx.doi.org/10.3390/md11083068 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Li, Chun-Shun
Li, Xiao-Ming
Gao, Shu-Shan
Lu, Yan-Hua
Wang, Bin-Gui
Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44
title Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44
title_full Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44
title_fullStr Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44
title_full_unstemmed Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44
title_short Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44
title_sort cytotoxic anthranilic acid derivatives from deep sea sediment-derived fungus penicillium paneum sd-44
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766882/
https://www.ncbi.nlm.nih.gov/pubmed/23966037
http://dx.doi.org/10.3390/md11083068
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