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Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells

In recent years, several studies have shown that vitamin k2 (VK2) has anticancer activity in a variety of cancer cells. The antitumor effects of VK2 in prostate cancer are currently not known. In the present study, we sought to characterize the anticancer potential of VK2 in both androgen-dependent...

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Autores principales: Samykutty, Abhilash, Shetty, Aditya V., Dakshinamoorthy, Gajalakshmi, Kalyanasundaram, Ramaswamy, Zheng, Gouxing, Chen, Aoshuang, Bosland, Maarten C., Kajdacsy-Balla, André, Gnanasekar, Munirathinam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767046/
https://www.ncbi.nlm.nih.gov/pubmed/24062781
http://dx.doi.org/10.1155/2013/287358
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author Samykutty, Abhilash
Shetty, Aditya V.
Dakshinamoorthy, Gajalakshmi
Kalyanasundaram, Ramaswamy
Zheng, Gouxing
Chen, Aoshuang
Bosland, Maarten C.
Kajdacsy-Balla, André
Gnanasekar, Munirathinam
author_facet Samykutty, Abhilash
Shetty, Aditya V.
Dakshinamoorthy, Gajalakshmi
Kalyanasundaram, Ramaswamy
Zheng, Gouxing
Chen, Aoshuang
Bosland, Maarten C.
Kajdacsy-Balla, André
Gnanasekar, Munirathinam
author_sort Samykutty, Abhilash
collection PubMed
description In recent years, several studies have shown that vitamin k2 (VK2) has anticancer activity in a variety of cancer cells. The antitumor effects of VK2 in prostate cancer are currently not known. In the present study, we sought to characterize the anticancer potential of VK2 in both androgen-dependent and -independent prostate cancer cells. Our investigations show that VK2 is able to suppress viability of androgen-dependent and androgen-independent prostate cancer cells via caspase-3 and -8 dependent apoptosis. We also show that VK2 treatment reduces androgen receptor expression and PSA secretion in androgen-dependent prostate cancer cells. Our results also implicate VK2 as a potential anti-inflammatory agent, as several inflammatory genes are downregulated in prostate cancer cells following treatment with VK2. Additionally, AKT and NF-kB levels in prostate cancer cells are reduced significantly when treated with VK2. These findings correlated with the results of the Boyden chamber and angiogenesis assay, as VK2 treatment reduced cell migration and angiogenesis potential of prostate cancer cells. Finally, in a nude mice model, VK2 administration resulted in significant inhibition of both androgen-dependent and androgen-independent tumor growth. Overall, our results suggest that VK2 may be a potential therapeutic agent in the treatment of prostate cancer.
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spelling pubmed-37670462013-09-23 Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells Samykutty, Abhilash Shetty, Aditya V. Dakshinamoorthy, Gajalakshmi Kalyanasundaram, Ramaswamy Zheng, Gouxing Chen, Aoshuang Bosland, Maarten C. Kajdacsy-Balla, André Gnanasekar, Munirathinam Evid Based Complement Alternat Med Research Article In recent years, several studies have shown that vitamin k2 (VK2) has anticancer activity in a variety of cancer cells. The antitumor effects of VK2 in prostate cancer are currently not known. In the present study, we sought to characterize the anticancer potential of VK2 in both androgen-dependent and -independent prostate cancer cells. Our investigations show that VK2 is able to suppress viability of androgen-dependent and androgen-independent prostate cancer cells via caspase-3 and -8 dependent apoptosis. We also show that VK2 treatment reduces androgen receptor expression and PSA secretion in androgen-dependent prostate cancer cells. Our results also implicate VK2 as a potential anti-inflammatory agent, as several inflammatory genes are downregulated in prostate cancer cells following treatment with VK2. Additionally, AKT and NF-kB levels in prostate cancer cells are reduced significantly when treated with VK2. These findings correlated with the results of the Boyden chamber and angiogenesis assay, as VK2 treatment reduced cell migration and angiogenesis potential of prostate cancer cells. Finally, in a nude mice model, VK2 administration resulted in significant inhibition of both androgen-dependent and androgen-independent tumor growth. Overall, our results suggest that VK2 may be a potential therapeutic agent in the treatment of prostate cancer. Hindawi Publishing Corporation 2013 2013-08-24 /pmc/articles/PMC3767046/ /pubmed/24062781 http://dx.doi.org/10.1155/2013/287358 Text en Copyright © 2013 Abhilash Samykutty et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Samykutty, Abhilash
Shetty, Aditya V.
Dakshinamoorthy, Gajalakshmi
Kalyanasundaram, Ramaswamy
Zheng, Gouxing
Chen, Aoshuang
Bosland, Maarten C.
Kajdacsy-Balla, André
Gnanasekar, Munirathinam
Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells
title Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells
title_full Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells
title_fullStr Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells
title_full_unstemmed Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells
title_short Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells
title_sort vitamin k2, a naturally occurring menaquinone, exerts therapeutic effects on both hormone-dependent and hormone-independent prostate cancer cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767046/
https://www.ncbi.nlm.nih.gov/pubmed/24062781
http://dx.doi.org/10.1155/2013/287358
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