A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity

A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H(5)IO(6)-SiO(2)) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup proce...

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Detalles Bibliográficos
Autores principales: Sontakke, Vyankat A., Ghosh, Sougata, Lawande, Pravin P., Chopade, Balu A., Shinde, Vaishali S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767211/
https://www.ncbi.nlm.nih.gov/pubmed/24052861
http://dx.doi.org/10.1155/2013/453682
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author Sontakke, Vyankat A.
Ghosh, Sougata
Lawande, Pravin P.
Chopade, Balu A.
Shinde, Vaishali S.
author_facet Sontakke, Vyankat A.
Ghosh, Sougata
Lawande, Pravin P.
Chopade, Balu A.
Shinde, Vaishali S.
author_sort Sontakke, Vyankat A.
collection PubMed
description A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H(5)IO(6)-SiO(2)) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell lines.
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spelling pubmed-37672112013-09-19 A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity Sontakke, Vyankat A. Ghosh, Sougata Lawande, Pravin P. Chopade, Balu A. Shinde, Vaishali S. ISRN Org Chem Research Article A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H(5)IO(6)-SiO(2)) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell lines. Hindawi Publishing Corporation 2013-04-24 /pmc/articles/PMC3767211/ /pubmed/24052861 http://dx.doi.org/10.1155/2013/453682 Text en Copyright © 2013 Vyankat A. Sontakke et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sontakke, Vyankat A.
Ghosh, Sougata
Lawande, Pravin P.
Chopade, Balu A.
Shinde, Vaishali S.
A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity
title A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity
title_full A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity
title_fullStr A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity
title_full_unstemmed A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity
title_short A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity
title_sort simple, efficient synthesis of 2-aryl benzimidazoles using silica supported periodic acid catalyst and evaluation of anticancer activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767211/
https://www.ncbi.nlm.nih.gov/pubmed/24052861
http://dx.doi.org/10.1155/2013/453682
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