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Seroprevalence of anti-HCV antibodies among blood donors of north India

BACKGROUND & OBJECTIVES: Transfusion of blood and blood products although considered as a life saving treatment modality, but may lead to certain infectious and non-infectious complications in the recipients. The purpose of this analysis was to monitor the seroprevalence of anti-HCV antibody in...

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Autores principales: Makroo, R.N., Walia, Rimpreet Singh, Chowdhry, Mohit, Bhatia, Aakanksha, Hegde, Vikas, Rosamma, N.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767252/
https://www.ncbi.nlm.nih.gov/pubmed/24056566
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author Makroo, R.N.
Walia, Rimpreet Singh
Chowdhry, Mohit
Bhatia, Aakanksha
Hegde, Vikas
Rosamma, N.L.
author_facet Makroo, R.N.
Walia, Rimpreet Singh
Chowdhry, Mohit
Bhatia, Aakanksha
Hegde, Vikas
Rosamma, N.L.
author_sort Makroo, R.N.
collection PubMed
description BACKGROUND & OBJECTIVES: Transfusion of blood and blood products although considered as a life saving treatment modality, but may lead to certain infectious and non-infectious complications in the recipients. The purpose of this analysis was to monitor the seroprevalence of anti-HCV antibody in the blood donor population in a hospital based blood bank in north India, to evaluate the trends over the years (2001-2011). METHODS: Relevant information of all the blood donors who donated whole blood at the department of Transfusion Medicine, Indraprastha Apollo Hospitals, New Delhi from the January 1, 2001 to December 31, 2011 was retrieved from the departmental records. The number of donors who were found reactive for anti-HCV anatibodies was calculated. RESULTS: Of the 2,06,022 blood donors, 1,93,661 were males and 12,361 were females. The percentage of whole blood donors found seroreactive for anti-HCV antibodies was 0.39 per cent (n=795). The seroprevalence of anti-HCV in male blood donors was 0.38 per cent (n=750) and the respective seroprevalence in female blood donors was 0.36 per cent (n=45). No significant change in the trend of HCV seroprevalence was observed over the period under consideration. Maximum seroprevalence of anti-HCV was observed in the age group of 18 to 30 yr (0.41%) and the minimum in the age group of 51 to 60 yr (0.26%). INTERPRETATION & CONCLUSION: HCV seroprevalence in our study was 0.39 per cent and a decreasing trend with age was observed. No significant change in the trend of anti-HCV seroprevalence was seen over a decade. Since, no vaccine is presently available for immunization against HCV infection, transfusion transmitted HCV infection remains a potential threat to the safety of the blood supply.
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spelling pubmed-37672522013-09-18 Seroprevalence of anti-HCV antibodies among blood donors of north India Makroo, R.N. Walia, Rimpreet Singh Chowdhry, Mohit Bhatia, Aakanksha Hegde, Vikas Rosamma, N.L. Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Transfusion of blood and blood products although considered as a life saving treatment modality, but may lead to certain infectious and non-infectious complications in the recipients. The purpose of this analysis was to monitor the seroprevalence of anti-HCV antibody in the blood donor population in a hospital based blood bank in north India, to evaluate the trends over the years (2001-2011). METHODS: Relevant information of all the blood donors who donated whole blood at the department of Transfusion Medicine, Indraprastha Apollo Hospitals, New Delhi from the January 1, 2001 to December 31, 2011 was retrieved from the departmental records. The number of donors who were found reactive for anti-HCV anatibodies was calculated. RESULTS: Of the 2,06,022 blood donors, 1,93,661 were males and 12,361 were females. The percentage of whole blood donors found seroreactive for anti-HCV antibodies was 0.39 per cent (n=795). The seroprevalence of anti-HCV in male blood donors was 0.38 per cent (n=750) and the respective seroprevalence in female blood donors was 0.36 per cent (n=45). No significant change in the trend of HCV seroprevalence was observed over the period under consideration. Maximum seroprevalence of anti-HCV was observed in the age group of 18 to 30 yr (0.41%) and the minimum in the age group of 51 to 60 yr (0.26%). INTERPRETATION & CONCLUSION: HCV seroprevalence in our study was 0.39 per cent and a decreasing trend with age was observed. No significant change in the trend of anti-HCV seroprevalence was seen over a decade. Since, no vaccine is presently available for immunization against HCV infection, transfusion transmitted HCV infection remains a potential threat to the safety of the blood supply. Medknow Publications & Media Pvt Ltd 2013-07 /pmc/articles/PMC3767252/ /pubmed/24056566 Text en Copyright: © The Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Makroo, R.N.
Walia, Rimpreet Singh
Chowdhry, Mohit
Bhatia, Aakanksha
Hegde, Vikas
Rosamma, N.L.
Seroprevalence of anti-HCV antibodies among blood donors of north India
title Seroprevalence of anti-HCV antibodies among blood donors of north India
title_full Seroprevalence of anti-HCV antibodies among blood donors of north India
title_fullStr Seroprevalence of anti-HCV antibodies among blood donors of north India
title_full_unstemmed Seroprevalence of anti-HCV antibodies among blood donors of north India
title_short Seroprevalence of anti-HCV antibodies among blood donors of north India
title_sort seroprevalence of anti-hcv antibodies among blood donors of north india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767252/
https://www.ncbi.nlm.nih.gov/pubmed/24056566
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