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Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy

BACKGROUND & OBJECTIVES: Iron deficiency anaemia (IDA) is the most common nutritional deficiency in pregnancy. Prophylactic oral iron is recommended during pregnancy to meet the increased requirement. In India, women become pregnant with low baseline haemoglobin level resulting in high incidence...

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Autores principales: Kriplani, Alka, Mahey, Reeta, Dash, Biswa Bhusan, Kulshreshta, Vidushi, Agarwal, Nutan, Bhatla, Neerja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767254/
https://www.ncbi.nlm.nih.gov/pubmed/24056559
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author Kriplani, Alka
Mahey, Reeta
Dash, Biswa Bhusan
Kulshreshta, Vidushi
Agarwal, Nutan
Bhatla, Neerja
author_facet Kriplani, Alka
Mahey, Reeta
Dash, Biswa Bhusan
Kulshreshta, Vidushi
Agarwal, Nutan
Bhatla, Neerja
author_sort Kriplani, Alka
collection PubMed
description BACKGROUND & OBJECTIVES: Iron deficiency anaemia (IDA) is the most common nutritional deficiency in pregnancy. Prophylactic oral iron is recommended during pregnancy to meet the increased requirement. In India, women become pregnant with low baseline haemoglobin level resulting in high incidence of moderate to severe anaemia in pregnancy where oral iron therapy cannot meet the requirement. Pregnant women with moderate anaemia are to be treated with parentral iron therapy. This study was undertaken to evaluate the response and effect of intravenous iron sucrose complex (ISC) given to pregnant women with IDA. METHODS: A prospective study was conducted (June 2009 to June 2011) in the department of Obstetrics & Gynecology, All India Institute of Medical Sciences, New Delhi. One hundred pregnant women with haemoglobin between 5-9 g% with diagnosed iron deficiency attending antenatal clinic were given intravenous iron sucrose complex in a dose of 200 mg twice weekly schedule after calculating the dose requirement. RESULTS: The mean haemoglobin raised from 7.63 ± 0.61 to 11.20 ± 0.73 g% (P<0.001) after eight wk of therapy. There was significant rise in serum ferritin levels (from 11.2 ± 4.7 to 69 ± 23.1 μg/l) (P<0.001). Reticulocyte count increased significantly after two wk of starting therapy (from 1.5 ± 0.6 to 4.6±0.8%). Other parameters including serum iron levels and red cell indices were also improved significantly. Only one woman was lost to follow up. No major side effects or anaphylactic reactions were noted during study period. INTERPRETATION & CONCLUSIONS: Parentral iron therapy was effective in increasing haemoglobin, serum ferritin and other haematological parameters in pregnant women with moderate anaemia. Intravenous iron sucrose can be used in hospital settings and tertiary urban hospitals where it can replace intramuscular therapy due to injection related side effects. Further, long-term comparative studies are required to recommend its use at peripheral level.
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spelling pubmed-37672542013-09-18 Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy Kriplani, Alka Mahey, Reeta Dash, Biswa Bhusan Kulshreshta, Vidushi Agarwal, Nutan Bhatla, Neerja Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Iron deficiency anaemia (IDA) is the most common nutritional deficiency in pregnancy. Prophylactic oral iron is recommended during pregnancy to meet the increased requirement. In India, women become pregnant with low baseline haemoglobin level resulting in high incidence of moderate to severe anaemia in pregnancy where oral iron therapy cannot meet the requirement. Pregnant women with moderate anaemia are to be treated with parentral iron therapy. This study was undertaken to evaluate the response and effect of intravenous iron sucrose complex (ISC) given to pregnant women with IDA. METHODS: A prospective study was conducted (June 2009 to June 2011) in the department of Obstetrics & Gynecology, All India Institute of Medical Sciences, New Delhi. One hundred pregnant women with haemoglobin between 5-9 g% with diagnosed iron deficiency attending antenatal clinic were given intravenous iron sucrose complex in a dose of 200 mg twice weekly schedule after calculating the dose requirement. RESULTS: The mean haemoglobin raised from 7.63 ± 0.61 to 11.20 ± 0.73 g% (P<0.001) after eight wk of therapy. There was significant rise in serum ferritin levels (from 11.2 ± 4.7 to 69 ± 23.1 μg/l) (P<0.001). Reticulocyte count increased significantly after two wk of starting therapy (from 1.5 ± 0.6 to 4.6±0.8%). Other parameters including serum iron levels and red cell indices were also improved significantly. Only one woman was lost to follow up. No major side effects or anaphylactic reactions were noted during study period. INTERPRETATION & CONCLUSIONS: Parentral iron therapy was effective in increasing haemoglobin, serum ferritin and other haematological parameters in pregnant women with moderate anaemia. Intravenous iron sucrose can be used in hospital settings and tertiary urban hospitals where it can replace intramuscular therapy due to injection related side effects. Further, long-term comparative studies are required to recommend its use at peripheral level. Medknow Publications & Media Pvt Ltd 2013-07 /pmc/articles/PMC3767254/ /pubmed/24056559 Text en Copyright: © The Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kriplani, Alka
Mahey, Reeta
Dash, Biswa Bhusan
Kulshreshta, Vidushi
Agarwal, Nutan
Bhatla, Neerja
Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy
title Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy
title_full Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy
title_fullStr Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy
title_full_unstemmed Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy
title_short Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy
title_sort intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767254/
https://www.ncbi.nlm.nih.gov/pubmed/24056559
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