Dramatic Response to Cisplatin Window Therapy in a Boy With Advanced Metastatic Ewing Sarcoma

Ewing sarcoma (ES) is the second most common type of primary bone malignancy, and retains a high propensity to metastasize; the prognosis of patients with disseminated disease is very poor, with an event-free survival rate of <20%. Current multimodality treatment for ES consists of combined chemo...

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Autores principales: Trizzino, Antonino, Ziino, Ottavio, Parafioriti, Antonina, Podda, Marta, Tropia, Serena, Luksch, Roberto, D’Angelo, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2013
Materias:
Clinical and Laboratory Observations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767273/
https://www.ncbi.nlm.nih.gov/pubmed/23892353
http://dx.doi.org/10.1097/MPH.0b013e31829d452c
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author Trizzino, Antonino
Ziino, Ottavio
Parafioriti, Antonina
Podda, Marta
Tropia, Serena
Luksch, Roberto
D’Angelo, Paolo
author_facet Trizzino, Antonino
Ziino, Ottavio
Parafioriti, Antonina
Podda, Marta
Tropia, Serena
Luksch, Roberto
D’Angelo, Paolo
author_sort Trizzino, Antonino
collection PubMed
description Ewing sarcoma (ES) is the second most common type of primary bone malignancy, and retains a high propensity to metastasize; the prognosis of patients with disseminated disease is very poor, with an event-free survival rate of <20%. Current multimodality treatment for ES consists of combined chemotherapy before and concurrent with surgery and local radiotherapy for the involved bone. Cisplatin is one of the most widely used drugs for the treatment of bone tumors in children, but is not currently used in ES. We describe a child with multifocal ES, treated with a phase II trial including a single-drug window therapy, which displayed a dramatic response to 2 courses of cisplatin and had a favorable outcome.
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spelling pubmed-37672732013-09-09 Dramatic Response to Cisplatin Window Therapy in a Boy With Advanced Metastatic Ewing Sarcoma Trizzino, Antonino Ziino, Ottavio Parafioriti, Antonina Podda, Marta Tropia, Serena Luksch, Roberto D’Angelo, Paolo J Pediatr Hematol Oncol Clinical and Laboratory Observations Ewing sarcoma (ES) is the second most common type of primary bone malignancy, and retains a high propensity to metastasize; the prognosis of patients with disseminated disease is very poor, with an event-free survival rate of <20%. Current multimodality treatment for ES consists of combined chemotherapy before and concurrent with surgery and local radiotherapy for the involved bone. Cisplatin is one of the most widely used drugs for the treatment of bone tumors in children, but is not currently used in ES. We describe a child with multifocal ES, treated with a phase II trial including a single-drug window therapy, which displayed a dramatic response to 2 courses of cisplatin and had a favorable outcome. Lippincott Williams & Wilkins 2013-08 2013-08-05 /pmc/articles/PMC3767273/ /pubmed/23892353 http://dx.doi.org/10.1097/MPH.0b013e31829d452c Text en Copyright © 2013 by Lippincott Williams & Wilkins http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Clinical and Laboratory Observations
Trizzino, Antonino
Ziino, Ottavio
Parafioriti, Antonina
Podda, Marta
Tropia, Serena
Luksch, Roberto
D’Angelo, Paolo
Dramatic Response to Cisplatin Window Therapy in a Boy With Advanced Metastatic Ewing Sarcoma
title Dramatic Response to Cisplatin Window Therapy in a Boy With Advanced Metastatic Ewing Sarcoma
title_full Dramatic Response to Cisplatin Window Therapy in a Boy With Advanced Metastatic Ewing Sarcoma
title_fullStr Dramatic Response to Cisplatin Window Therapy in a Boy With Advanced Metastatic Ewing Sarcoma
title_full_unstemmed Dramatic Response to Cisplatin Window Therapy in a Boy With Advanced Metastatic Ewing Sarcoma
title_short Dramatic Response to Cisplatin Window Therapy in a Boy With Advanced Metastatic Ewing Sarcoma
title_sort dramatic response to cisplatin window therapy in a boy with advanced metastatic ewing sarcoma
topic Clinical and Laboratory Observations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767273/
https://www.ncbi.nlm.nih.gov/pubmed/23892353
http://dx.doi.org/10.1097/MPH.0b013e31829d452c
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