Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation

The present investigation summarizes the effect of Linum usitatissimum fixed oil against different phases of acute inflammatory reaction, namely, protein exudation, peritoneal capillary permeability, and leukocyte migration. The fixed oil exhibited dose-dependent inhibition of protein exudation vasc...

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Detalles Bibliográficos
Autores principales: Kaithwas, Gaurav, Majumdar, Dipak K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767321/
https://www.ncbi.nlm.nih.gov/pubmed/24049663
http://dx.doi.org/10.1155/2013/735158
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author Kaithwas, Gaurav
Majumdar, Dipak K.
author_facet Kaithwas, Gaurav
Majumdar, Dipak K.
author_sort Kaithwas, Gaurav
collection PubMed
description The present investigation summarizes the effect of Linum usitatissimum fixed oil against different phases of acute inflammatory reaction, namely, protein exudation, peritoneal capillary permeability, and leukocyte migration. The fixed oil exhibited dose-dependent inhibition of protein exudation vascular permeability, comparable to standard aspirin. The oil also inhibited the leukocyte migration in pleural exudates in a dose-dependent manner. Production of less vasodilatory (PGE(3)) and chemotactic (LTB(5)) eicosanoids through EPA (derived from linolenic acid) metabolism could account for the above observations.
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spelling pubmed-37673212013-09-18 Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation Kaithwas, Gaurav Majumdar, Dipak K. ISRN Inflamm Research Article The present investigation summarizes the effect of Linum usitatissimum fixed oil against different phases of acute inflammatory reaction, namely, protein exudation, peritoneal capillary permeability, and leukocyte migration. The fixed oil exhibited dose-dependent inhibition of protein exudation vascular permeability, comparable to standard aspirin. The oil also inhibited the leukocyte migration in pleural exudates in a dose-dependent manner. Production of less vasodilatory (PGE(3)) and chemotactic (LTB(5)) eicosanoids through EPA (derived from linolenic acid) metabolism could account for the above observations. Hindawi Publishing Corporation 2013-02-17 /pmc/articles/PMC3767321/ /pubmed/24049663 http://dx.doi.org/10.1155/2013/735158 Text en Copyright © 2013 G. Kaithwas and D. K. Majumdar. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kaithwas, Gaurav
Majumdar, Dipak K.
Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation
title Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation
title_full Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation
title_fullStr Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation
title_full_unstemmed Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation
title_short Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation
title_sort effect of l. usitatissimum (flaxseed/linseed) fixed oil against distinct phases of inflammation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767321/
https://www.ncbi.nlm.nih.gov/pubmed/24049663
http://dx.doi.org/10.1155/2013/735158
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