Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils

Six new 2-o-(m- and p-)chlorobenzylthio-6-methyl-5-piperidino-(or morpholino-) methyluracils have been prepared. The structures of these compounds were confirmed by spectroscopic (FT-IR, UV-Vis, (1)H NMR, (13)C NMR, and HMBC) and elemental analyses. Estimation of pharmacotherapeutic potential has be...

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Autores principales: Pospieszny, Tomasz, Szymankiewicz, Marcin, Wyrzykiewicz, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767325/
https://www.ncbi.nlm.nih.gov/pubmed/24052828
http://dx.doi.org/10.5402/2011/610521
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author Pospieszny, Tomasz
Szymankiewicz, Marcin
Wyrzykiewicz, Elżbieta
author_facet Pospieszny, Tomasz
Szymankiewicz, Marcin
Wyrzykiewicz, Elżbieta
author_sort Pospieszny, Tomasz
collection PubMed
description Six new 2-o-(m- and p-)chlorobenzylthio-6-methyl-5-piperidino-(or morpholino-) methyluracils have been prepared. The structures of these compounds were confirmed by spectroscopic (FT-IR, UV-Vis, (1)H NMR, (13)C NMR, and HMBC) and elemental analyses. Estimation of pharmacotherapeutic potential has been made for synthesized compounds on the basis of prediction of activity spectra for substances (PASS).
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spelling pubmed-37673252013-09-19 Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils Pospieszny, Tomasz Szymankiewicz, Marcin Wyrzykiewicz, Elżbieta ISRN Org Chem Research Article Six new 2-o-(m- and p-)chlorobenzylthio-6-methyl-5-piperidino-(or morpholino-) methyluracils have been prepared. The structures of these compounds were confirmed by spectroscopic (FT-IR, UV-Vis, (1)H NMR, (13)C NMR, and HMBC) and elemental analyses. Estimation of pharmacotherapeutic potential has been made for synthesized compounds on the basis of prediction of activity spectra for substances (PASS). International Scholarly Research Network 2011-04-07 /pmc/articles/PMC3767325/ /pubmed/24052828 http://dx.doi.org/10.5402/2011/610521 Text en Copyright © 2011 Tomasz Pospieszny et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pospieszny, Tomasz
Szymankiewicz, Marcin
Wyrzykiewicz, Elżbieta
Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils
title Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils
title_full Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils
title_fullStr Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils
title_full_unstemmed Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils
title_short Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils
title_sort thio analogs of pyrimidine bases: synthesis, spectroscopic study, and in silico biological activity evaluation of new 2-o-(m- and p-)chlorobenzylthio-6-methyl-5-piperidino-(morpholino-)methyluracils
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767325/
https://www.ncbi.nlm.nih.gov/pubmed/24052828
http://dx.doi.org/10.5402/2011/610521
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