General Approach to the Synthesis of Prochiral Atropisomeric Biaryls

General approach to the synthesis of prochiral precursors of chiral atropisomeric biaryls based on several complementary methods has been developed. Biaryls were obtained in good to excellent yields depending on their structure and selected method of synthesis. Furthermore, we demonstrate a possibil...

Descripción completa

Detalles Bibliográficos
Autores principales: Kielar, Katarzyna, Demchuk, Oleg M., Pietrusiewicz, K. Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767330/
https://www.ncbi.nlm.nih.gov/pubmed/24052833
http://dx.doi.org/10.5402/2011/919102
Descripción
Sumario:General approach to the synthesis of prochiral precursors of chiral atropisomeric biaryls based on several complementary methods has been developed. Biaryls were obtained in good to excellent yields depending on their structure and selected method of synthesis. Furthermore, we demonstrate a possibility of utilisation of the obtained compounds possessing 2 or 3 ortho substituents around the aryl-aryl bond in direct and directed arylation reaction leading through transition metal-mediated C–H bond activation to atropisomeric compounds.

Ejemplares similares