General Approach to the Synthesis of Prochiral Atropisomeric Biaryls

General approach to the synthesis of prochiral precursors of chiral atropisomeric biaryls based on several complementary methods has been developed. Biaryls were obtained in good to excellent yields depending on their structure and selected method of synthesis. Furthermore, we demonstrate a possibil...

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Detalles Bibliográficos
Autores principales: Kielar, Katarzyna, Demchuk, Oleg M., Pietrusiewicz, K. Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767330/
https://www.ncbi.nlm.nih.gov/pubmed/24052833
http://dx.doi.org/10.5402/2011/919102
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author Kielar, Katarzyna
Demchuk, Oleg M.
Pietrusiewicz, K. Michał
author_facet Kielar, Katarzyna
Demchuk, Oleg M.
Pietrusiewicz, K. Michał
author_sort Kielar, Katarzyna
collection PubMed
description General approach to the synthesis of prochiral precursors of chiral atropisomeric biaryls based on several complementary methods has been developed. Biaryls were obtained in good to excellent yields depending on their structure and selected method of synthesis. Furthermore, we demonstrate a possibility of utilisation of the obtained compounds possessing 2 or 3 ortho substituents around the aryl-aryl bond in direct and directed arylation reaction leading through transition metal-mediated C–H bond activation to atropisomeric compounds.
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spelling pubmed-37673302013-09-19 General Approach to the Synthesis of Prochiral Atropisomeric Biaryls Kielar, Katarzyna Demchuk, Oleg M. Pietrusiewicz, K. Michał ISRN Org Chem Research Article General approach to the synthesis of prochiral precursors of chiral atropisomeric biaryls based on several complementary methods has been developed. Biaryls were obtained in good to excellent yields depending on their structure and selected method of synthesis. Furthermore, we demonstrate a possibility of utilisation of the obtained compounds possessing 2 or 3 ortho substituents around the aryl-aryl bond in direct and directed arylation reaction leading through transition metal-mediated C–H bond activation to atropisomeric compounds. International Scholarly Research Network 2011-06-26 /pmc/articles/PMC3767330/ /pubmed/24052833 http://dx.doi.org/10.5402/2011/919102 Text en Copyright © 2011 Katarzyna Kielar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kielar, Katarzyna
Demchuk, Oleg M.
Pietrusiewicz, K. Michał
General Approach to the Synthesis of Prochiral Atropisomeric Biaryls
title General Approach to the Synthesis of Prochiral Atropisomeric Biaryls
title_full General Approach to the Synthesis of Prochiral Atropisomeric Biaryls
title_fullStr General Approach to the Synthesis of Prochiral Atropisomeric Biaryls
title_full_unstemmed General Approach to the Synthesis of Prochiral Atropisomeric Biaryls
title_short General Approach to the Synthesis of Prochiral Atropisomeric Biaryls
title_sort general approach to the synthesis of prochiral atropisomeric biaryls
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767330/
https://www.ncbi.nlm.nih.gov/pubmed/24052833
http://dx.doi.org/10.5402/2011/919102
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