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Anogenital Lesions: Kaposi's Sarcoma and Its Mimicks

Kaposi's sarcoma (KS) is a low-grade vascular neoplasm associated with human herpes virus-8 (HHV-8) infection, and, in the epidemic form, with the human immunodeficiency virus (HIV). Although HHV-8 is present in all body fluids and is sexually transmitted, there are surprisingly few reports of...

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Autor principal: van Bogaert, Louis-Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767349/
https://www.ncbi.nlm.nih.gov/pubmed/24052876
http://dx.doi.org/10.5402/2012/486425
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author van Bogaert, Louis-Jacques
author_facet van Bogaert, Louis-Jacques
author_sort van Bogaert, Louis-Jacques
collection PubMed
description Kaposi's sarcoma (KS) is a low-grade vascular neoplasm associated with human herpes virus-8 (HHV-8) infection, and, in the epidemic form, with the human immunodeficiency virus (HIV). Although HHV-8 is present in all body fluids and is sexually transmitted, there are surprisingly few reports of anogenital KS. Clinically, especially in HIV/KS endemic areas, dark stained skin patches or nodules are prone to misdiagnosis, especially in dark-skinned individuals. Therefore, a biopsy is recommended. The histologic appearance spans a broad spectrum of KS and non-KS lesions; therefore, the final diagnosis should be confirmed by HHV-8 immunohistochemistry. We report a series of 36 anogenital biopsies from a group of 16 documented HIV-positive patients; in 20 the HIV serostatus was unknown. There were ten KS (five in HIV-positive patients), and 26 non-KS (11 in HIV-positive subjects) lesions. In the era of HIV/AIDS, anogenital lesions may be the first manifestation of KS in immunocompromised individuals and should be biopsied. The histological diagnosis should be confirmed by HHV-8 immunohistochemistry.
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spelling pubmed-37673492013-09-19 Anogenital Lesions: Kaposi's Sarcoma and Its Mimicks van Bogaert, Louis-Jacques ISRN AIDS Clinical Study Kaposi's sarcoma (KS) is a low-grade vascular neoplasm associated with human herpes virus-8 (HHV-8) infection, and, in the epidemic form, with the human immunodeficiency virus (HIV). Although HHV-8 is present in all body fluids and is sexually transmitted, there are surprisingly few reports of anogenital KS. Clinically, especially in HIV/KS endemic areas, dark stained skin patches or nodules are prone to misdiagnosis, especially in dark-skinned individuals. Therefore, a biopsy is recommended. The histologic appearance spans a broad spectrum of KS and non-KS lesions; therefore, the final diagnosis should be confirmed by HHV-8 immunohistochemistry. We report a series of 36 anogenital biopsies from a group of 16 documented HIV-positive patients; in 20 the HIV serostatus was unknown. There were ten KS (five in HIV-positive patients), and 26 non-KS (11 in HIV-positive subjects) lesions. In the era of HIV/AIDS, anogenital lesions may be the first manifestation of KS in immunocompromised individuals and should be biopsied. The histological diagnosis should be confirmed by HHV-8 immunohistochemistry. International Scholarly Research Network 2012-10-31 /pmc/articles/PMC3767349/ /pubmed/24052876 http://dx.doi.org/10.5402/2012/486425 Text en Copyright © 2012 Louis-Jacques van Bogaert. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
van Bogaert, Louis-Jacques
Anogenital Lesions: Kaposi's Sarcoma and Its Mimicks
title Anogenital Lesions: Kaposi's Sarcoma and Its Mimicks
title_full Anogenital Lesions: Kaposi's Sarcoma and Its Mimicks
title_fullStr Anogenital Lesions: Kaposi's Sarcoma and Its Mimicks
title_full_unstemmed Anogenital Lesions: Kaposi's Sarcoma and Its Mimicks
title_short Anogenital Lesions: Kaposi's Sarcoma and Its Mimicks
title_sort anogenital lesions: kaposi's sarcoma and its mimicks
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767349/
https://www.ncbi.nlm.nih.gov/pubmed/24052876
http://dx.doi.org/10.5402/2012/486425
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