The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition

The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of (13)C-labeled odorants. The application of (13)C isotopomers is discussed herein by means of DFT-calcu...

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Detalles Bibliográficos
Autor principal: Klika, Karel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767358/
https://www.ncbi.nlm.nih.gov/pubmed/24052862
http://dx.doi.org/10.1155/2013/515810
Descripción
Sumario:The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of (13)C-labeled odorants. The application of (13)C isotopomers is discussed herein by means of DFT-calculated IR vibrations and Gibbs' free energies (ΔG) for acetophenone and octan-1-ol, two odorants for which the (2)D (deuterium) isotopomers have previously been shown to be discernible from their respective (1)H (normal) counterparts by Drosophila melanogaster.

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