The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition

The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of (13)C-labeled odorants. The application of (13)C isotopomers is discussed herein by means of DFT-calcu...

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Autor principal: Klika, Karel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767358/
https://www.ncbi.nlm.nih.gov/pubmed/24052862
http://dx.doi.org/10.1155/2013/515810
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author Klika, Karel D.
author_facet Klika, Karel D.
author_sort Klika, Karel D.
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description The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of (13)C-labeled odorants. The application of (13)C isotopomers is discussed herein by means of DFT-calculated IR vibrations and Gibbs' free energies (ΔG) for acetophenone and octan-1-ol, two odorants for which the (2)D (deuterium) isotopomers have previously been shown to be discernible from their respective (1)H (normal) counterparts by Drosophila melanogaster.
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spelling pubmed-37673582013-09-19 The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition Klika, Karel D. ISRN Org Chem Research Article The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of (13)C-labeled odorants. The application of (13)C isotopomers is discussed herein by means of DFT-calculated IR vibrations and Gibbs' free energies (ΔG) for acetophenone and octan-1-ol, two odorants for which the (2)D (deuterium) isotopomers have previously been shown to be discernible from their respective (1)H (normal) counterparts by Drosophila melanogaster. Hindawi Publishing Corporation 2013-05-26 /pmc/articles/PMC3767358/ /pubmed/24052862 http://dx.doi.org/10.1155/2013/515810 Text en Copyright © 2013 Karel D. Klika. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Klika, Karel D.
The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition
title The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition
title_full The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition
title_fullStr The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition
title_full_unstemmed The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition
title_short The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition
title_sort potential of 13c isotopomers as a test for the vibrational theory of olfactory sense recognition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767358/
https://www.ncbi.nlm.nih.gov/pubmed/24052862
http://dx.doi.org/10.1155/2013/515810
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