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The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition
The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of (13)C-labeled odorants. The application of (13)C isotopomers is discussed herein by means of DFT-calcu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767358/ https://www.ncbi.nlm.nih.gov/pubmed/24052862 http://dx.doi.org/10.1155/2013/515810 |
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author | Klika, Karel D. |
author_facet | Klika, Karel D. |
author_sort | Klika, Karel D. |
collection | PubMed |
description | The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of (13)C-labeled odorants. The application of (13)C isotopomers is discussed herein by means of DFT-calculated IR vibrations and Gibbs' free energies (ΔG) for acetophenone and octan-1-ol, two odorants for which the (2)D (deuterium) isotopomers have previously been shown to be discernible from their respective (1)H (normal) counterparts by Drosophila melanogaster. |
format | Online Article Text |
id | pubmed-3767358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37673582013-09-19 The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition Klika, Karel D. ISRN Org Chem Research Article The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of (13)C-labeled odorants. The application of (13)C isotopomers is discussed herein by means of DFT-calculated IR vibrations and Gibbs' free energies (ΔG) for acetophenone and octan-1-ol, two odorants for which the (2)D (deuterium) isotopomers have previously been shown to be discernible from their respective (1)H (normal) counterparts by Drosophila melanogaster. Hindawi Publishing Corporation 2013-05-26 /pmc/articles/PMC3767358/ /pubmed/24052862 http://dx.doi.org/10.1155/2013/515810 Text en Copyright © 2013 Karel D. Klika. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Klika, Karel D. The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition |
title | The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition |
title_full | The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition |
title_fullStr | The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition |
title_full_unstemmed | The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition |
title_short | The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition |
title_sort | potential of 13c isotopomers as a test for the vibrational theory of olfactory sense recognition |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767358/ https://www.ncbi.nlm.nih.gov/pubmed/24052862 http://dx.doi.org/10.1155/2013/515810 |
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