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Collagen: A potential factor involved in the pathogenesis of glaucoma

Numerous studies have been completed on glaucoma pathogenesis. However, the potential and controversial interaction between ocular biomechanical properties and the glaucomatous diseases process has received much more attention recently. Previous studies have found that collagen tissues gain mutation...

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Autores principales: Huang, Wenbin, Fan, Qian, Wang, Wei, Zhou, Minwen, Laties, Alan M., Zhang, Xiulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767582/
https://www.ncbi.nlm.nih.gov/pubmed/24002298
http://dx.doi.org/10.12659/MSMBR.889061
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author Huang, Wenbin
Fan, Qian
Wang, Wei
Zhou, Minwen
Laties, Alan M.
Zhang, Xiulan
author_facet Huang, Wenbin
Fan, Qian
Wang, Wei
Zhou, Minwen
Laties, Alan M.
Zhang, Xiulan
author_sort Huang, Wenbin
collection PubMed
description Numerous studies have been completed on glaucoma pathogenesis. However, the potential and controversial interaction between ocular biomechanical properties and the glaucomatous diseases process has received much more attention recently. Previous studies have found that collagen tissues gain mutation change in glaucoma patients. This study was conducted to determine the role of collagen in the biomechanics of glaucoma in humans. Its changes may be the result of mechanical modifications brought on by intraocular pressure (IOP) fluctuations. More importantly, biomechanics and genetic evidence indicate that the mutation of collagen may play a role in the process of glaucoma. Alteration of collagen in the outflow pathway may alter mechanical tissue characteristics and a concomitant increase of aqueous humor outflow resistance and elevation of IOP. The variations of collagen, leading to inter-individual differences in scleral and lamina cribrosa properties, result in different susceptibility of individuals to elevated IOP. Therefore, this study hypothesized that collagen mutations may be an original cause of glaucoma.
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spelling pubmed-37675822013-09-10 Collagen: A potential factor involved in the pathogenesis of glaucoma Huang, Wenbin Fan, Qian Wang, Wei Zhou, Minwen Laties, Alan M. Zhang, Xiulan Med Sci Monit Basic Res Hypothesis Numerous studies have been completed on glaucoma pathogenesis. However, the potential and controversial interaction between ocular biomechanical properties and the glaucomatous diseases process has received much more attention recently. Previous studies have found that collagen tissues gain mutation change in glaucoma patients. This study was conducted to determine the role of collagen in the biomechanics of glaucoma in humans. Its changes may be the result of mechanical modifications brought on by intraocular pressure (IOP) fluctuations. More importantly, biomechanics and genetic evidence indicate that the mutation of collagen may play a role in the process of glaucoma. Alteration of collagen in the outflow pathway may alter mechanical tissue characteristics and a concomitant increase of aqueous humor outflow resistance and elevation of IOP. The variations of collagen, leading to inter-individual differences in scleral and lamina cribrosa properties, result in different susceptibility of individuals to elevated IOP. Therefore, this study hypothesized that collagen mutations may be an original cause of glaucoma. International Scientific Literature, Inc. 2013-09-04 /pmc/articles/PMC3767582/ /pubmed/24002298 http://dx.doi.org/10.12659/MSMBR.889061 Text en © Med Sci Monit, 2013 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Hypothesis
Huang, Wenbin
Fan, Qian
Wang, Wei
Zhou, Minwen
Laties, Alan M.
Zhang, Xiulan
Collagen: A potential factor involved in the pathogenesis of glaucoma
title Collagen: A potential factor involved in the pathogenesis of glaucoma
title_full Collagen: A potential factor involved in the pathogenesis of glaucoma
title_fullStr Collagen: A potential factor involved in the pathogenesis of glaucoma
title_full_unstemmed Collagen: A potential factor involved in the pathogenesis of glaucoma
title_short Collagen: A potential factor involved in the pathogenesis of glaucoma
title_sort collagen: a potential factor involved in the pathogenesis of glaucoma
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767582/
https://www.ncbi.nlm.nih.gov/pubmed/24002298
http://dx.doi.org/10.12659/MSMBR.889061
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