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Mechanism of Porcine Liver Xanthine Oxidoreductase Mediated N-Oxide Reduction of Cyadox as Revealed by Docking and Mutagenesis Studies

Xanthine oxidoreductase (XOR) is a cytoplasmic molybdenum-containing oxidoreductase, catalyzing both endogenous purines and exogenous compounds. It is suggested that XOR in porcine hepatocytes catalyzes the N-oxide reduction of quinoxaline 1,4-di-N-oxides (QdNOs). To elucidate the molecular mechanis...

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Detalles Bibliográficos
Autores principales:	Chen, Chigang, Cheng, Guyue, Hao, Haihong, Dai, Menghong, Wang, Xu, Huang, Lingli, Liu, Zhenli, Yuan, Zonghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767608/ https://www.ncbi.nlm.nih.gov/pubmed/24040113 http://dx.doi.org/10.1371/journal.pone.0073912

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