Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids in Cellular Recovery after Quinone Exposure

Toxicity screening of compounds provides a means to identify compounds harmful for human health and the environment. Here, we further develop the technique of genomic phenotyping to improve throughput while maintaining specificity. We exposed cells to eight different compounds that rely on different...

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Detalles Bibliográficos
Autores principales: Svensson, J. Peter, Quirós Pesudo, Laia, McRee, Siobhan K., Adeleye, Yeyejide, Carmichael, Paul, Samson, Leona D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767620/
https://www.ncbi.nlm.nih.gov/pubmed/24040048
http://dx.doi.org/10.1371/journal.pone.0073736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767620/
https://www.ncbi.nlm.nih.gov/pubmed/24040048
http://dx.doi.org/10.1371/journal.pone.0073736

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