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Cognitive Reserve in Granulin-Related Frontotemporal Dementia: from Preclinical to Clinical Stages
OBJECTIVE: Consistent with the cognitive reserve hypothesis, higher education and occupation attainments may help persons with neurodegenerative dementias to better withstand neuropathology before developing cognitive impairment. We tested here the cognitive reserve hypothesis in patients with front...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767639/ https://www.ncbi.nlm.nih.gov/pubmed/24040338 http://dx.doi.org/10.1371/journal.pone.0074762 |
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author | Premi, Enrico Gazzina, Stefano Bozzali, Marco Archetti, Silvana Alberici, Antonella Cercignani, Mara Bianchetti, Angelo Gasparotti, Roberto Turla, Marinella Caltagirone, Carlo Padovani, Alessandro Borroni, Barbara |
author_facet | Premi, Enrico Gazzina, Stefano Bozzali, Marco Archetti, Silvana Alberici, Antonella Cercignani, Mara Bianchetti, Angelo Gasparotti, Roberto Turla, Marinella Caltagirone, Carlo Padovani, Alessandro Borroni, Barbara |
author_sort | Premi, Enrico |
collection | PubMed |
description | OBJECTIVE: Consistent with the cognitive reserve hypothesis, higher education and occupation attainments may help persons with neurodegenerative dementias to better withstand neuropathology before developing cognitive impairment. We tested here the cognitive reserve hypothesis in patients with frontotemporal dementia (FTD), with or without pathogenetic granulin mutations (GRN+ and GRN-), and in presymptomatic GRN mutation carriers (aGRN+). METHODS: Education and occupation attainments were assessed and combined to define Reserve Index (RI) in 32 FTD patients, i.e. 12 GRN+ and 20 GRN-, and in 17 aGRN+. Changes in functional connectivity were estimated by resting state fMRI, focusing on the salience network (SN), executive network (EN) and bilateral frontoparietal networks (FPNs). Cognitive status was measured by FTD-modified Clinical Dementia Rating Scale. RESULTS: In FTD patients higher level of premorbid cognitive reserve was associated with reduced connectivity within the SN and the EN. EN was more involved in FTD patients without GRN mutations, while SN was more affected in GRN pathology. In aGRN+, cognitive reserve was associated with reduced SN. CONCLUSIONS: This study suggests that cognitive reserve modulates functional connectivity in patients with FTD, even in monogenic disease. In GRN inherited FTD, cognitive reserve mechanisms operate even in presymptomatic to clinical stages. |
format | Online Article Text |
id | pubmed-3767639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37676392013-09-13 Cognitive Reserve in Granulin-Related Frontotemporal Dementia: from Preclinical to Clinical Stages Premi, Enrico Gazzina, Stefano Bozzali, Marco Archetti, Silvana Alberici, Antonella Cercignani, Mara Bianchetti, Angelo Gasparotti, Roberto Turla, Marinella Caltagirone, Carlo Padovani, Alessandro Borroni, Barbara PLoS One Research Article OBJECTIVE: Consistent with the cognitive reserve hypothesis, higher education and occupation attainments may help persons with neurodegenerative dementias to better withstand neuropathology before developing cognitive impairment. We tested here the cognitive reserve hypothesis in patients with frontotemporal dementia (FTD), with or without pathogenetic granulin mutations (GRN+ and GRN-), and in presymptomatic GRN mutation carriers (aGRN+). METHODS: Education and occupation attainments were assessed and combined to define Reserve Index (RI) in 32 FTD patients, i.e. 12 GRN+ and 20 GRN-, and in 17 aGRN+. Changes in functional connectivity were estimated by resting state fMRI, focusing on the salience network (SN), executive network (EN) and bilateral frontoparietal networks (FPNs). Cognitive status was measured by FTD-modified Clinical Dementia Rating Scale. RESULTS: In FTD patients higher level of premorbid cognitive reserve was associated with reduced connectivity within the SN and the EN. EN was more involved in FTD patients without GRN mutations, while SN was more affected in GRN pathology. In aGRN+, cognitive reserve was associated with reduced SN. CONCLUSIONS: This study suggests that cognitive reserve modulates functional connectivity in patients with FTD, even in monogenic disease. In GRN inherited FTD, cognitive reserve mechanisms operate even in presymptomatic to clinical stages. Public Library of Science 2013-09-09 /pmc/articles/PMC3767639/ /pubmed/24040338 http://dx.doi.org/10.1371/journal.pone.0074762 Text en © 2013 Premi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Premi, Enrico Gazzina, Stefano Bozzali, Marco Archetti, Silvana Alberici, Antonella Cercignani, Mara Bianchetti, Angelo Gasparotti, Roberto Turla, Marinella Caltagirone, Carlo Padovani, Alessandro Borroni, Barbara Cognitive Reserve in Granulin-Related Frontotemporal Dementia: from Preclinical to Clinical Stages |
title | Cognitive Reserve in Granulin-Related Frontotemporal Dementia: from Preclinical to Clinical Stages |
title_full | Cognitive Reserve in Granulin-Related Frontotemporal Dementia: from Preclinical to Clinical Stages |
title_fullStr | Cognitive Reserve in Granulin-Related Frontotemporal Dementia: from Preclinical to Clinical Stages |
title_full_unstemmed | Cognitive Reserve in Granulin-Related Frontotemporal Dementia: from Preclinical to Clinical Stages |
title_short | Cognitive Reserve in Granulin-Related Frontotemporal Dementia: from Preclinical to Clinical Stages |
title_sort | cognitive reserve in granulin-related frontotemporal dementia: from preclinical to clinical stages |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767639/ https://www.ncbi.nlm.nih.gov/pubmed/24040338 http://dx.doi.org/10.1371/journal.pone.0074762 |
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