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Synergistic Apoptosis of CML Cells by Buthionine Sulfoximine and Hydroxychavicol Correlates with Activation of AIF and GSH-ROS-JNK-ERK-iNOS Pathway

BACKGROUND: Hydroxychavicol (HCH), a constituent of Piper betle leaf has been reported to exert anti-leukemic activity through induction of reactive oxygen species (ROS). The aim of the study is to optimize the oxidative stress –induced chronic myeloid leukemic (CML) cell death by combining glutathi...

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Detalles Bibliográficos
Autores principales:	Chowdhury, Avik Acharya, Chaudhuri, Jaydeep, Biswas, Nabendu, Manna, Anirban, Chatterjee, Saurav, Mahato, Sanjit K., Chaudhuri, Utpal, Jaisankar, Parasuraman, Bandyopadhyay, Santu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767640/ https://www.ncbi.nlm.nih.gov/pubmed/24040019 http://dx.doi.org/10.1371/journal.pone.0073672

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