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Chromatin Changes in Dicer-Deficient Mouse Embryonic Stem Cells in Response to Retinoic Acid Induced Differentiation

Loss of Dicer, an enzyme critical for microRNA biogenesis, results in lethality due to a block in mouse embryonic stem cell (mES) differentiation. Using ChIP-Seq we found increased H3K9me2 at over 900 CpG islands in the Dicer(-/-)ES epigenome. Gene ontology analysis revealed that promoters of chroma...

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Detalles Bibliográficos
Autores principales:	Tennakoon, Jayantha B., Wang, Hongran, Coarfa, Cristian, Cooney, Austin J., Gunaratne, Preethi H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767645/ https://www.ncbi.nlm.nih.gov/pubmed/24040281 http://dx.doi.org/10.1371/journal.pone.0074556

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