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Testing the Ability of Non-Methylamine Osmolytes Present in Kidney Cells to Counteract the Deleterious Effects of Urea on Structure, Stability and Function of Proteins

Human kidney cells are under constant urea stress due to its urine concentrating mechanism. It is believed that the deleterious effect of urea is counteracted by methylamine osmolytes (glycine betaine and glycerophosphocholine) present in kidney cells. A question arises: Do the stabilizing osmolytes...

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Detalles Bibliográficos
Autores principales:	Khan, Sheeza, Bano, Zehra, Singh, Laishram R., Hassan, Md. Imtaiyaz, Islam, Asimul, Ahmad, Faizan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767660/ https://www.ncbi.nlm.nih.gov/pubmed/24039776 http://dx.doi.org/10.1371/journal.pone.0072533

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