Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients

We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression leve...

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Detalles Bibliográficos
Autores principales: Cloke, Tom, Munder, Markus, Bergin, Philip, Herath, Shanthi, Modolell, Manuel, Taylor, Graham, Müller, Ingrid, Kropf, Pascale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767740/
https://www.ncbi.nlm.nih.gov/pubmed/24039734
http://dx.doi.org/10.1371/journal.pone.0072034
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author Cloke, Tom
Munder, Markus
Bergin, Philip
Herath, Shanthi
Modolell, Manuel
Taylor, Graham
Müller, Ingrid
Kropf, Pascale
author_facet Cloke, Tom
Munder, Markus
Bergin, Philip
Herath, Shanthi
Modolell, Manuel
Taylor, Graham
Müller, Ingrid
Kropf, Pascale
author_sort Cloke, Tom
collection PubMed
description We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV seropositive patients at different stages of HIV infection to determine whether the phenotype of NDGs and LDGs are affected by disease severity. Our results reveal that the phenotype of NDGs, but not that of LDGs, varies according to the severity of the disease.
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spelling pubmed-37677402013-09-13 Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients Cloke, Tom Munder, Markus Bergin, Philip Herath, Shanthi Modolell, Manuel Taylor, Graham Müller, Ingrid Kropf, Pascale PLoS One Research Article We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV seropositive patients at different stages of HIV infection to determine whether the phenotype of NDGs and LDGs are affected by disease severity. Our results reveal that the phenotype of NDGs, but not that of LDGs, varies according to the severity of the disease. Public Library of Science 2013-09-09 /pmc/articles/PMC3767740/ /pubmed/24039734 http://dx.doi.org/10.1371/journal.pone.0072034 Text en © 2013 Cloke et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Cloke, Tom
Munder, Markus
Bergin, Philip
Herath, Shanthi
Modolell, Manuel
Taylor, Graham
Müller, Ingrid
Kropf, Pascale
Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients
title Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients
title_full Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients
title_fullStr Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients
title_full_unstemmed Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients
title_short Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients
title_sort phenotypic alteration of neutrophils in the blood of hiv seropositive patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767740/
https://www.ncbi.nlm.nih.gov/pubmed/24039734
http://dx.doi.org/10.1371/journal.pone.0072034
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