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PKD1 Mediates Negative Feedback of PI3K/Akt Activation in Response to G Protein-Coupled Receptors

We examined whether protein kinase D1 (PKD1) mediates negative feeback of PI3K/Akt signaling in intestinal epithelial cells stimulated with G protein-coupled receptor (GPCR) agonists. Exposure of intestinal epithelial IEC-18 cells to increasing concentrations of the PKD family inhibitor kb NB 14270...

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Detalles Bibliográficos
Autores principales:	Ni, Yang, Sinnett-Smith, James, Young, Steven H., Rozengurt, Enrique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767810/ https://www.ncbi.nlm.nih.gov/pubmed/24039875 http://dx.doi.org/10.1371/journal.pone.0073149

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