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PIKfyve Regulates the Endosomal Localization of CpG Oligodeoxynucleotides to Elicit TLR9-Dependent Cellular Responses

TLR9 is a receptor for oligodeoxynucleotides that contain unmethylated CpG motifs (CpG). Because TLR9 resides in the endoplasmic reticulum during the quiescence state, CpG binding to TLR9 requires membrane trafficking, which includes the maturation of the CpG-containing endosome. In the present stud...

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Detalles Bibliográficos
Autores principales:	Hazeki, Kaoru, Uehara, Masami, Nigorikawa, Kiyomi, Hazeki, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767827/ https://www.ncbi.nlm.nih.gov/pubmed/24040108 http://dx.doi.org/10.1371/journal.pone.0073894

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