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Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons
Neurons are extremely polarized structures with long axons and dendrites, which require proper distribution of mitochondria and maintenance of mitochondrial dynamics for neuronal functions and survival. Indeed, recent studies show that various neurological disorders are linked to mitochondrial trans...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767916/ https://www.ncbi.nlm.nih.gov/pubmed/24058334 http://dx.doi.org/10.3389/fncel.2013.00148 |
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author | Niescier, Robert F. Chang, Karen T. Min, Kyung-Tai |
author_facet | Niescier, Robert F. Chang, Karen T. Min, Kyung-Tai |
author_sort | Niescier, Robert F. |
collection | PubMed |
description | Neurons are extremely polarized structures with long axons and dendrites, which require proper distribution of mitochondria and maintenance of mitochondrial dynamics for neuronal functions and survival. Indeed, recent studies show that various neurological disorders are linked to mitochondrial transport in neurons. Mitochondrial anterograde transport is believed to deliver metabolic energy to synaptic terminals where energy demands are high, while mitochondrial retrograde transport is required to repair or remove damaged mitochondria in axons. It has been suggested that Ca(2)(+) plays a key role in regulating mitochondrial transport by altering the configuration of mitochondrial protein, miro. However, molecular mechanisms that regulate mitochondrial transport in neurons still are not well characterized. In this review, we will discuss the roles of miro in mitochondrial transport and how the recently identified components of the mitochondrial calcium uniporter add to our current model of mitochondrial mobility regulation. |
format | Online Article Text |
id | pubmed-3767916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37679162013-09-20 Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons Niescier, Robert F. Chang, Karen T. Min, Kyung-Tai Front Cell Neurosci Neuroscience Neurons are extremely polarized structures with long axons and dendrites, which require proper distribution of mitochondria and maintenance of mitochondrial dynamics for neuronal functions and survival. Indeed, recent studies show that various neurological disorders are linked to mitochondrial transport in neurons. Mitochondrial anterograde transport is believed to deliver metabolic energy to synaptic terminals where energy demands are high, while mitochondrial retrograde transport is required to repair or remove damaged mitochondria in axons. It has been suggested that Ca(2)(+) plays a key role in regulating mitochondrial transport by altering the configuration of mitochondrial protein, miro. However, molecular mechanisms that regulate mitochondrial transport in neurons still are not well characterized. In this review, we will discuss the roles of miro in mitochondrial transport and how the recently identified components of the mitochondrial calcium uniporter add to our current model of mitochondrial mobility regulation. Frontiers Media S.A. 2013-09-10 /pmc/articles/PMC3767916/ /pubmed/24058334 http://dx.doi.org/10.3389/fncel.2013.00148 Text en Copyright © Niescier, Chang and Min. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Niescier, Robert F. Chang, Karen T. Min, Kyung-Tai Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
title | Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
title_full | Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
title_fullStr | Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
title_full_unstemmed | Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
title_short | Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons |
title_sort | miro, mcu, and calcium: bridging our understanding of mitochondrial movement in axons |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767916/ https://www.ncbi.nlm.nih.gov/pubmed/24058334 http://dx.doi.org/10.3389/fncel.2013.00148 |
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