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Prevalence of antibodies to Sarcocystis neurona and Neospora hughesi in horses from Mexico

Equine protozoal myeloencephalitis (EPM) is a debilitating disease of horses caused by Sarcocystis neurona and Neospora hughesi. Sera from 495 horses in Durango State, Mexico were tested for anti-protozoal antibodies using enzyme-linked immunosorbent assays (ELISAs) based on major surface antigens o...

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Autores principales: Yeargan, Michelle R., Alvarado-Esquivel, Cosme, Dubey, Jitender P., Howe, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: EDP Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767921/
https://www.ncbi.nlm.nih.gov/pubmed/24016396
http://dx.doi.org/10.1051/parasite/2013029
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author Yeargan, Michelle R.
Alvarado-Esquivel, Cosme
Dubey, Jitender P.
Howe, Daniel K.
author_facet Yeargan, Michelle R.
Alvarado-Esquivel, Cosme
Dubey, Jitender P.
Howe, Daniel K.
author_sort Yeargan, Michelle R.
collection PubMed
description Equine protozoal myeloencephalitis (EPM) is a debilitating disease of horses caused by Sarcocystis neurona and Neospora hughesi. Sera from 495 horses in Durango State, Mexico were tested for anti-protozoal antibodies using enzyme-linked immunosorbent assays (ELISAs) based on major surface antigens of these two parasites. Antibodies to S. neurona were detected in 240 (48.5%) of the 495 horse sera tested with the rSnSAG2/4/3 trivalent ELISA. Multivariate analysis showed that exposure to S. neurona was associated with age, feeding grains and crops, and small herd size. Antibodies to N. hughesi were found in 15 (3.0%) of the 495 horse sera tested with the rNhSAG1 ELISA and confirmed by Western blot of N. hughesi tachyzoite antigen. This is the first report of S. neurona and N. hughesi exposure in horses in Mexico, and it affirms that EPM should be in the differential diagnosis for horses exhibiting signs of neurologic disease in this country.
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spelling pubmed-37679212013-09-13 Prevalence of antibodies to Sarcocystis neurona and Neospora hughesi in horses from Mexico Yeargan, Michelle R. Alvarado-Esquivel, Cosme Dubey, Jitender P. Howe, Daniel K. Parasite Short Note Equine protozoal myeloencephalitis (EPM) is a debilitating disease of horses caused by Sarcocystis neurona and Neospora hughesi. Sera from 495 horses in Durango State, Mexico were tested for anti-protozoal antibodies using enzyme-linked immunosorbent assays (ELISAs) based on major surface antigens of these two parasites. Antibodies to S. neurona were detected in 240 (48.5%) of the 495 horse sera tested with the rSnSAG2/4/3 trivalent ELISA. Multivariate analysis showed that exposure to S. neurona was associated with age, feeding grains and crops, and small herd size. Antibodies to N. hughesi were found in 15 (3.0%) of the 495 horse sera tested with the rNhSAG1 ELISA and confirmed by Western blot of N. hughesi tachyzoite antigen. This is the first report of S. neurona and N. hughesi exposure in horses in Mexico, and it affirms that EPM should be in the differential diagnosis for horses exhibiting signs of neurologic disease in this country. EDP Sciences 2013 2013-09-10 /pmc/articles/PMC3767921/ /pubmed/24016396 http://dx.doi.org/10.1051/parasite/2013029 Text en © M.R. Yeargan et al., published by EDP Sciences, 2013 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Note
Yeargan, Michelle R.
Alvarado-Esquivel, Cosme
Dubey, Jitender P.
Howe, Daniel K.
Prevalence of antibodies to Sarcocystis neurona and Neospora hughesi in horses from Mexico
title Prevalence of antibodies to Sarcocystis neurona and Neospora hughesi in horses from Mexico
title_full Prevalence of antibodies to Sarcocystis neurona and Neospora hughesi in horses from Mexico
title_fullStr Prevalence of antibodies to Sarcocystis neurona and Neospora hughesi in horses from Mexico
title_full_unstemmed Prevalence of antibodies to Sarcocystis neurona and Neospora hughesi in horses from Mexico
title_short Prevalence of antibodies to Sarcocystis neurona and Neospora hughesi in horses from Mexico
title_sort prevalence of antibodies to sarcocystis neurona and neospora hughesi in horses from mexico
topic Short Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767921/
https://www.ncbi.nlm.nih.gov/pubmed/24016396
http://dx.doi.org/10.1051/parasite/2013029
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