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Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering
Recent experiments have revealed that some membrane proteins aggregate to form clusters. This type of process has been proven to be dynamic and to be actively maintained by external kinetics. Additionally, this dynamic recruiting is cholesterol- and actin-dependent, suggesting that raft organization...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767946/ https://www.ncbi.nlm.nih.gov/pubmed/24018870 http://dx.doi.org/10.1038/srep02608 |
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author | Gómez-Llobregat, Jordi Buceta, Javier Reigada, Ramon |
author_facet | Gómez-Llobregat, Jordi Buceta, Javier Reigada, Ramon |
author_sort | Gómez-Llobregat, Jordi |
collection | PubMed |
description | Recent experiments have revealed that some membrane proteins aggregate to form clusters. This type of process has been proven to be dynamic and to be actively maintained by external kinetics. Additionally, this dynamic recruiting is cholesterol- and actin-dependent, suggesting that raft organization and cytoskeleton rearrangement play a crucial role. In the present study, we propose a simple model that provides a general framework to describe the dynamical behavior of lipid-protein assemblies. Our results suggest that lipid-mediated interactions and cytoskeleton-anchored proteins contribute to the modulation of such behavior. In particular, we find a resonant condition between the membrane protein and cytoskeleton dynamics that results in the invariance of the ratio of clustered proteins that is found in in vivo experimental observations. |
format | Online Article Text |
id | pubmed-3767946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-37679462013-09-11 Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering Gómez-Llobregat, Jordi Buceta, Javier Reigada, Ramon Sci Rep Article Recent experiments have revealed that some membrane proteins aggregate to form clusters. This type of process has been proven to be dynamic and to be actively maintained by external kinetics. Additionally, this dynamic recruiting is cholesterol- and actin-dependent, suggesting that raft organization and cytoskeleton rearrangement play a crucial role. In the present study, we propose a simple model that provides a general framework to describe the dynamical behavior of lipid-protein assemblies. Our results suggest that lipid-mediated interactions and cytoskeleton-anchored proteins contribute to the modulation of such behavior. In particular, we find a resonant condition between the membrane protein and cytoskeleton dynamics that results in the invariance of the ratio of clustered proteins that is found in in vivo experimental observations. Nature Publishing Group 2013-09-10 /pmc/articles/PMC3767946/ /pubmed/24018870 http://dx.doi.org/10.1038/srep02608 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Gómez-Llobregat, Jordi Buceta, Javier Reigada, Ramon Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering |
title | Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering |
title_full | Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering |
title_fullStr | Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering |
title_full_unstemmed | Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering |
title_short | Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering |
title_sort | interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767946/ https://www.ncbi.nlm.nih.gov/pubmed/24018870 http://dx.doi.org/10.1038/srep02608 |
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