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Impaction grafting of the acetabulum with ceramic bone graft substitute: High survivorship in 43 patients with a mean follow-up period of 4 years

BACKGROUND AND PURPOSE: Loss of bone stock remains a challenge in revision hip surgery. Grafting with allograft is well established, but there are problems with availability, cost, infection, antigenicity, reproducibility, and stability of the created construct. BoneSave is a biphasic porous ceramic...

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Autores principales: Whitehouse, Michael R, Dacombe, Peter J, Webb, Jason C J, Blom, Ashley W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2013
Materias:
Hip
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768036/
https://www.ncbi.nlm.nih.gov/pubmed/23992140
http://dx.doi.org/10.3109/17453674.2013.824801
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author Whitehouse, Michael R
Dacombe, Peter J
Webb, Jason C J
Blom, Ashley W
author_facet Whitehouse, Michael R
Dacombe, Peter J
Webb, Jason C J
Blom, Ashley W
author_sort Whitehouse, Michael R
collection PubMed
description BACKGROUND AND PURPOSE: Loss of bone stock remains a challenge in revision hip surgery. Grafting with allograft is well established, but there are problems with availability, cost, infection, antigenicity, reproducibility, and stability of the created construct. BoneSave is a biphasic porous ceramic consisting of sintered 80% tricalcium phosphate and 20% hydroxyapatite. In vitro and in vivo studies, including its use mixed with allograft, have shown good results in impaction grafting. This is the first reported series of its use alone in impaction grafting of the acetabulum. METHODS: Methods We conducted a retrospective review of a cohort of 43 consecutive patients undergoing impaction grafting of contained acetabular defects by multiple surgeons at a single centre. All patients received uncemented acetabular components. They were followed up radiographically, together with self-reported satisfaction scale (SAPS), Oxford hip score (OHS), and Short-Form 12 (SF12) health survey. Kaplan-Meier survivorship analysis was performed with revision of the acetabular component, revision of any part of the construct, and reoperation as endpoints. RESULTS: The fate of all cases was known. Mean follow-up was 4 years. 5 patients died during follow-up, with their constructs in situ. The survivorship of the acetabular component was 98% (95% CI: 85–100) at 7 years. 1 acetabular component was revised for infection and there was 1 radiographic acetabular failure. The median OHS was 36 (6–48), the median SF12 PCS was 36 (14–57), the median SAPS was 75 (0–100), and the median SF12 MCS was 50 (23–64). The graft material had incorporated in all 3 zones of the acetabulum in 33 out of 37 cases with complete radiographic follow-up. INTERPRETATION: Medium-term results show that BoneSave alone is a reliable material for impaction grafting of contained defects in the acetabulum at revision surgery.
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spelling pubmed-37680362013-09-16 Impaction grafting of the acetabulum with ceramic bone graft substitute: High survivorship in 43 patients with a mean follow-up period of 4 years Whitehouse, Michael R Dacombe, Peter J Webb, Jason C J Blom, Ashley W Acta Orthop Hip BACKGROUND AND PURPOSE: Loss of bone stock remains a challenge in revision hip surgery. Grafting with allograft is well established, but there are problems with availability, cost, infection, antigenicity, reproducibility, and stability of the created construct. BoneSave is a biphasic porous ceramic consisting of sintered 80% tricalcium phosphate and 20% hydroxyapatite. In vitro and in vivo studies, including its use mixed with allograft, have shown good results in impaction grafting. This is the first reported series of its use alone in impaction grafting of the acetabulum. METHODS: Methods We conducted a retrospective review of a cohort of 43 consecutive patients undergoing impaction grafting of contained acetabular defects by multiple surgeons at a single centre. All patients received uncemented acetabular components. They were followed up radiographically, together with self-reported satisfaction scale (SAPS), Oxford hip score (OHS), and Short-Form 12 (SF12) health survey. Kaplan-Meier survivorship analysis was performed with revision of the acetabular component, revision of any part of the construct, and reoperation as endpoints. RESULTS: The fate of all cases was known. Mean follow-up was 4 years. 5 patients died during follow-up, with their constructs in situ. The survivorship of the acetabular component was 98% (95% CI: 85–100) at 7 years. 1 acetabular component was revised for infection and there was 1 radiographic acetabular failure. The median OHS was 36 (6–48), the median SF12 PCS was 36 (14–57), the median SAPS was 75 (0–100), and the median SF12 MCS was 50 (23–64). The graft material had incorporated in all 3 zones of the acetabulum in 33 out of 37 cases with complete radiographic follow-up. INTERPRETATION: Medium-term results show that BoneSave alone is a reliable material for impaction grafting of contained defects in the acetabulum at revision surgery. Informa Healthcare 2013-08 2013-09-02 /pmc/articles/PMC3768036/ /pubmed/23992140 http://dx.doi.org/10.3109/17453674.2013.824801 Text en Copyright: © Nordic Orthopaedic Federation http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Hip
Whitehouse, Michael R
Dacombe, Peter J
Webb, Jason C J
Blom, Ashley W
Impaction grafting of the acetabulum with ceramic bone graft substitute: High survivorship in 43 patients with a mean follow-up period of 4 years
title Impaction grafting of the acetabulum with ceramic bone graft substitute: High survivorship in 43 patients with a mean follow-up period of 4 years
title_full Impaction grafting of the acetabulum with ceramic bone graft substitute: High survivorship in 43 patients with a mean follow-up period of 4 years
title_fullStr Impaction grafting of the acetabulum with ceramic bone graft substitute: High survivorship in 43 patients with a mean follow-up period of 4 years
title_full_unstemmed Impaction grafting of the acetabulum with ceramic bone graft substitute: High survivorship in 43 patients with a mean follow-up period of 4 years
title_short Impaction grafting of the acetabulum with ceramic bone graft substitute: High survivorship in 43 patients with a mean follow-up period of 4 years
title_sort impaction grafting of the acetabulum with ceramic bone graft substitute: high survivorship in 43 patients with a mean follow-up period of 4 years
topic Hip
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768036/
https://www.ncbi.nlm.nih.gov/pubmed/23992140
http://dx.doi.org/10.3109/17453674.2013.824801
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