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Periodontitis, diabetes mellitus, and the lopsided redox balance: A unifying axis

AIM: The aim of present study was to evaluate and compare the total antioxidant capacity in the saliva of type 2 diabetes mellitus (DM) patients and healthy subjects, with and without periodontal disease. MATERIALS AND METHODS: The study was designed as a case–control study, comprising of 120 male s...

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Autores principales: Pendyala, Gowri, Thomas, Biju, Joshi, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768185/
https://www.ncbi.nlm.nih.gov/pubmed/24049335
http://dx.doi.org/10.4103/0972-124X.115661
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author Pendyala, Gowri
Thomas, Biju
Joshi, Saurabh
author_facet Pendyala, Gowri
Thomas, Biju
Joshi, Saurabh
author_sort Pendyala, Gowri
collection PubMed
description AIM: The aim of present study was to evaluate and compare the total antioxidant capacity in the saliva of type 2 diabetes mellitus (DM) patients and healthy subjects, with and without periodontal disease. MATERIALS AND METHODS: The study was designed as a case–control study, comprising of 120 male subjects, who were divided into four groups of 30 patients each. Group I: Thirty type 2 diabetic males with periodontal disease; Group II: Thirty type 2 diabetic males without periodontal disease; Group III: Thirty healthy males with periodontal disease; Group IV: Thirty healthy males without periodontal disease. After clinical measurement and sampling, the total antioxidant capacities in the saliva of type 2 diabetic and healthy men were determined, and the data were tested by non-parametric tests. The total antioxidant capacity of the clinical samples was determined spectrophotometrically. RESULTS: The total antioxidant capacity in the saliva was the lowest in type 2 diabetic males with periodontal disease. The results were statistically significant. CONCLUSION: The findings of our study finally conclude that the salivary total antioxidant capacity is affected in type 2 diabetic males, in addition to the impact of periodontal disease, and hence, can be used as a useful marker of periodontitis in healthy and diabetic patients.
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spelling pubmed-37681852013-09-18 Periodontitis, diabetes mellitus, and the lopsided redox balance: A unifying axis Pendyala, Gowri Thomas, Biju Joshi, Saurabh J Indian Soc Periodontol Original Article AIM: The aim of present study was to evaluate and compare the total antioxidant capacity in the saliva of type 2 diabetes mellitus (DM) patients and healthy subjects, with and without periodontal disease. MATERIALS AND METHODS: The study was designed as a case–control study, comprising of 120 male subjects, who were divided into four groups of 30 patients each. Group I: Thirty type 2 diabetic males with periodontal disease; Group II: Thirty type 2 diabetic males without periodontal disease; Group III: Thirty healthy males with periodontal disease; Group IV: Thirty healthy males without periodontal disease. After clinical measurement and sampling, the total antioxidant capacities in the saliva of type 2 diabetic and healthy men were determined, and the data were tested by non-parametric tests. The total antioxidant capacity of the clinical samples was determined spectrophotometrically. RESULTS: The total antioxidant capacity in the saliva was the lowest in type 2 diabetic males with periodontal disease. The results were statistically significant. CONCLUSION: The findings of our study finally conclude that the salivary total antioxidant capacity is affected in type 2 diabetic males, in addition to the impact of periodontal disease, and hence, can be used as a useful marker of periodontitis in healthy and diabetic patients. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3768185/ /pubmed/24049335 http://dx.doi.org/10.4103/0972-124X.115661 Text en Copyright: © Journal of Indian Society of Periodontology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pendyala, Gowri
Thomas, Biju
Joshi, Saurabh
Periodontitis, diabetes mellitus, and the lopsided redox balance: A unifying axis
title Periodontitis, diabetes mellitus, and the lopsided redox balance: A unifying axis
title_full Periodontitis, diabetes mellitus, and the lopsided redox balance: A unifying axis
title_fullStr Periodontitis, diabetes mellitus, and the lopsided redox balance: A unifying axis
title_full_unstemmed Periodontitis, diabetes mellitus, and the lopsided redox balance: A unifying axis
title_short Periodontitis, diabetes mellitus, and the lopsided redox balance: A unifying axis
title_sort periodontitis, diabetes mellitus, and the lopsided redox balance: a unifying axis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768185/
https://www.ncbi.nlm.nih.gov/pubmed/24049335
http://dx.doi.org/10.4103/0972-124X.115661
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