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Growth factor signaling and memory formation: temporal and spatial integration of a molecular network

Growth factor (GF) signaling is critically important for developmental plasticity. It also plays a crucial role in adult plasticity, such as that required for memory formation. Although different GFs interact with receptors containing distinct types of kinase domains, they typically signal through c...

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Detalles Bibliográficos
Autores principales: Kopec, Ashley M., Carew, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768197/
https://www.ncbi.nlm.nih.gov/pubmed/24042849
http://dx.doi.org/10.1101/lm.031377.113
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author Kopec, Ashley M.
Carew, Thomas J.
author_facet Kopec, Ashley M.
Carew, Thomas J.
author_sort Kopec, Ashley M.
collection PubMed
description Growth factor (GF) signaling is critically important for developmental plasticity. It also plays a crucial role in adult plasticity, such as that required for memory formation. Although different GFs interact with receptors containing distinct types of kinase domains, they typically signal through converging intracellular cascades (e.g., Ras–MEK–MAPK) to mediate overlapping functional endpoints. Several GFs have been implicated in memory formation, but due to a high level of convergent signaling, the unique contributions of individual GFs as well as the interactions between GF signaling cascades during the induction of memory is not well known. In this review, we highlight the unique roles of specific GFs in dendritic plasticity, and discuss the spatial and temporal profiles of different GFs during memory formation. Collectively, the data suggest that the roles of GF signaling in long-lasting behavioral and structural plasticity may be best viewed as interactive components in a complex molecular network.
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spelling pubmed-37681972014-10-01 Growth factor signaling and memory formation: temporal and spatial integration of a molecular network Kopec, Ashley M. Carew, Thomas J. Learn Mem Review Growth factor (GF) signaling is critically important for developmental plasticity. It also plays a crucial role in adult plasticity, such as that required for memory formation. Although different GFs interact with receptors containing distinct types of kinase domains, they typically signal through converging intracellular cascades (e.g., Ras–MEK–MAPK) to mediate overlapping functional endpoints. Several GFs have been implicated in memory formation, but due to a high level of convergent signaling, the unique contributions of individual GFs as well as the interactions between GF signaling cascades during the induction of memory is not well known. In this review, we highlight the unique roles of specific GFs in dendritic plasticity, and discuss the spatial and temporal profiles of different GFs during memory formation. Collectively, the data suggest that the roles of GF signaling in long-lasting behavioral and structural plasticity may be best viewed as interactive components in a complex molecular network. Cold Spring Harbor Laboratory Press 2013-10 /pmc/articles/PMC3768197/ /pubmed/24042849 http://dx.doi.org/10.1101/lm.031377.113 Text en © 2013, Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.
spellingShingle Review
Kopec, Ashley M.
Carew, Thomas J.
Growth factor signaling and memory formation: temporal and spatial integration of a molecular network
title Growth factor signaling and memory formation: temporal and spatial integration of a molecular network
title_full Growth factor signaling and memory formation: temporal and spatial integration of a molecular network
title_fullStr Growth factor signaling and memory formation: temporal and spatial integration of a molecular network
title_full_unstemmed Growth factor signaling and memory formation: temporal and spatial integration of a molecular network
title_short Growth factor signaling and memory formation: temporal and spatial integration of a molecular network
title_sort growth factor signaling and memory formation: temporal and spatial integration of a molecular network
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768197/
https://www.ncbi.nlm.nih.gov/pubmed/24042849
http://dx.doi.org/10.1101/lm.031377.113
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