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Autoimmune pancreatitis
Autoimmune pancreatitis (AIP) is a rare, heterogeneous, fibroinflammatory disorder of the pancreas. It has gained increasing recognition due to a presentation that can mimic difficult-to-treat disorders such as pancreatic cancer, cholangiocarcinoma and primary sclerosing cholangitis. In contrast, au...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768278/ https://www.ncbi.nlm.nih.gov/pubmed/24759664 http://dx.doi.org/10.1093/gastro/got011 |
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author | Ketwaroo, Gyanprakash A. Sheth, Sunil |
author_facet | Ketwaroo, Gyanprakash A. Sheth, Sunil |
author_sort | Ketwaroo, Gyanprakash A. |
collection | PubMed |
description | Autoimmune pancreatitis (AIP) is a rare, heterogeneous, fibroinflammatory disorder of the pancreas. It has gained increasing recognition due to a presentation that can mimic difficult-to-treat disorders such as pancreatic cancer, cholangiocarcinoma and primary sclerosing cholangitis. In contrast, autoimmune pancreatitis is a benign disease that is very responsive to therapy with corticosteroids. There are two types of AIP. Type 1 disease is the most common worldwide and is associated with extrapancreatic manifestations and elevated levels of IgG4-positive cells. Type 2 AIP is characterized by a paucity of IgG4-positive cells and is more difficult to diagnose. This review provides an update on the diagnosis, pathophysiology and treatment of AIP, with special emphasis on the two subtypes. |
format | Online Article Text |
id | pubmed-3768278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-37682782013-10-04 Autoimmune pancreatitis Ketwaroo, Gyanprakash A. Sheth, Sunil Gastroenterol Rep (Oxf) Reviews Autoimmune pancreatitis (AIP) is a rare, heterogeneous, fibroinflammatory disorder of the pancreas. It has gained increasing recognition due to a presentation that can mimic difficult-to-treat disorders such as pancreatic cancer, cholangiocarcinoma and primary sclerosing cholangitis. In contrast, autoimmune pancreatitis is a benign disease that is very responsive to therapy with corticosteroids. There are two types of AIP. Type 1 disease is the most common worldwide and is associated with extrapancreatic manifestations and elevated levels of IgG4-positive cells. Type 2 AIP is characterized by a paucity of IgG4-positive cells and is more difficult to diagnose. This review provides an update on the diagnosis, pathophysiology and treatment of AIP, with special emphasis on the two subtypes. Oxford University Press 2013-07 2013-03-28 /pmc/articles/PMC3768278/ /pubmed/24759664 http://dx.doi.org/10.1093/gastro/got011 Text en © The Author(s) 2013. Published by Oxford University Press and the Digestive Science Publishing Co. Limited. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Ketwaroo, Gyanprakash A. Sheth, Sunil Autoimmune pancreatitis |
title | Autoimmune pancreatitis |
title_full | Autoimmune pancreatitis |
title_fullStr | Autoimmune pancreatitis |
title_full_unstemmed | Autoimmune pancreatitis |
title_short | Autoimmune pancreatitis |
title_sort | autoimmune pancreatitis |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768278/ https://www.ncbi.nlm.nih.gov/pubmed/24759664 http://dx.doi.org/10.1093/gastro/got011 |
work_keys_str_mv | AT ketwaroogyanprakasha autoimmunepancreatitis AT shethsunil autoimmunepancreatitis |