Production of actinomycin-D by the mutant of a new isolate of Streptomyces sindenensis

An actinomycin-D producing strain was isolated from soil and characterized as Streptomyces sindenensis. The culture was subjected to UV irradiation and a mutant with 400% higher actinomycin-D production was isolated (400 mg/l(-1) as compared to 80 mg/l(-1) produced by the parent). Production medium...

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Detalles Bibliográficos
Autores principales: Praveen, Vandana, Tripathi, C.K.M., Bihari, Vinod, Srivastava, S.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2008
Materias:
Industrial Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768484/
https://www.ncbi.nlm.nih.gov/pubmed/24031290
http://dx.doi.org/10.1590/S1517-838220080004000017
Descripción
Sumario:An actinomycin-D producing strain was isolated from soil and characterized as Streptomyces sindenensis. The culture was subjected to UV irradiation and a mutant with 400% higher actinomycin-D production was isolated (400 mg/l(-1) as compared to 80 mg/l(-1) produced by the parent). Production medium was optimized and antibiotic yield with the mutant was enhanced to 850 mg/l(-1) which is 963% higher as compared with the parent.

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