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Molecular epidemiology of Shigella spp strains isolated in two different metropolitam areas of southeast Brazil

Shigella spp., the human pathogen responsible for shigellosis, is highly infectious even at low levels. The incidence rate of shigellosis varies with geographical distribution, location human development index, and age groups, being higher among children aged under 5 years. In Brazil, a few works in...

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Autores principales: Angelini, Michelle, Stehling, Eliana Guedes, Moretti, Maria Luiza, da Silveira, Wanderley Dias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768556/
https://www.ncbi.nlm.nih.gov/pubmed/24031415
http://dx.doi.org/10.1590/S1517-838220090003000034
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author Angelini, Michelle
Stehling, Eliana Guedes
Moretti, Maria Luiza
da Silveira, Wanderley Dias
author_facet Angelini, Michelle
Stehling, Eliana Guedes
Moretti, Maria Luiza
da Silveira, Wanderley Dias
author_sort Angelini, Michelle
collection PubMed
description Shigella spp., the human pathogen responsible for shigellosis, is highly infectious even at low levels. The incidence rate of shigellosis varies with geographical distribution, location human development index, and age groups, being higher among children aged under 5 years. In Brazil, a few works indicate that shigellosis cases are underestimated, with S. flexneri and S. sonnei strains being the major agents responsible for the shigellosis cases. The present study used pulsed field gel electrophoresis (PFGE) to investigate the molecular epidemiology of 119 strains of S. sonnei and S. flexneri isolated from shigellosis cases that occurred in the metropolitan areas of Ribeirão Preto and Campinas Cities, São Paulo Sate, southeast Brazil. The results indicated (i) the existence of just a few strain clusters for both species, but with genotype variability with either a high speed of genetic change or constant introduction of several genotypes, considering the intense migration to these two metropolitan areas, and (ii) the prevalence of specific genotypes in each geographical area, which suggests the successful adaptation of some genotypes to the local environmental conditions. Our results indicate the need of more efficacious sanitary barriers to prevent Shigella spp. outbreaks and epidemics.
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spelling pubmed-37685562013-09-12 Molecular epidemiology of Shigella spp strains isolated in two different metropolitam areas of southeast Brazil Angelini, Michelle Stehling, Eliana Guedes Moretti, Maria Luiza da Silveira, Wanderley Dias Braz J Microbiol Medical Microbiology Shigella spp., the human pathogen responsible for shigellosis, is highly infectious even at low levels. The incidence rate of shigellosis varies with geographical distribution, location human development index, and age groups, being higher among children aged under 5 years. In Brazil, a few works indicate that shigellosis cases are underestimated, with S. flexneri and S. sonnei strains being the major agents responsible for the shigellosis cases. The present study used pulsed field gel electrophoresis (PFGE) to investigate the molecular epidemiology of 119 strains of S. sonnei and S. flexneri isolated from shigellosis cases that occurred in the metropolitan areas of Ribeirão Preto and Campinas Cities, São Paulo Sate, southeast Brazil. The results indicated (i) the existence of just a few strain clusters for both species, but with genotype variability with either a high speed of genetic change or constant introduction of several genotypes, considering the intense migration to these two metropolitan areas, and (ii) the prevalence of specific genotypes in each geographical area, which suggests the successful adaptation of some genotypes to the local environmental conditions. Our results indicate the need of more efficacious sanitary barriers to prevent Shigella spp. outbreaks and epidemics. Sociedade Brasileira de Microbiologia 2009 2009-09-01 /pmc/articles/PMC3768556/ /pubmed/24031415 http://dx.doi.org/10.1590/S1517-838220090003000034 Text en © Sociedade Brasileira de Microbiologia http://creativecommons.org/licenses/by-nc/3.0/ All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License
spellingShingle Medical Microbiology
Angelini, Michelle
Stehling, Eliana Guedes
Moretti, Maria Luiza
da Silveira, Wanderley Dias
Molecular epidemiology of Shigella spp strains isolated in two different metropolitam areas of southeast Brazil
title Molecular epidemiology of Shigella spp strains isolated in two different metropolitam areas of southeast Brazil
title_full Molecular epidemiology of Shigella spp strains isolated in two different metropolitam areas of southeast Brazil
title_fullStr Molecular epidemiology of Shigella spp strains isolated in two different metropolitam areas of southeast Brazil
title_full_unstemmed Molecular epidemiology of Shigella spp strains isolated in two different metropolitam areas of southeast Brazil
title_short Molecular epidemiology of Shigella spp strains isolated in two different metropolitam areas of southeast Brazil
title_sort molecular epidemiology of shigella spp strains isolated in two different metropolitam areas of southeast brazil
topic Medical Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768556/
https://www.ncbi.nlm.nih.gov/pubmed/24031415
http://dx.doi.org/10.1590/S1517-838220090003000034
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