Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen

This study investigated the prevalence of the precore G1896A mutation in Chinese patients with hepatitis B e antigen (HBeAg) negative HBV infection and its relation to serum HBV pre-S1 antigen. The overall prevalence of the precore G1896A mutation was 72.6% in HBeAg-negative Chinese patients with de...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Jing, Xu, Wei-Jia, Wang, Qing, Zhang, Yong, Shi, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2009
Materias:
Medical Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768560/
https://www.ncbi.nlm.nih.gov/pubmed/24031448
http://dx.doi.org/10.1590/S1517-838220090004000031
_version_ 1782283814546964480
author Zhang, Jing
Xu, Wei-Jia
Wang, Qing
Zhang, Yong
Shi, Ming
author_facet Zhang, Jing
Xu, Wei-Jia
Wang, Qing
Zhang, Yong
Shi, Ming
author_sort Zhang, Jing
collection PubMed
description This study investigated the prevalence of the precore G1896A mutation in Chinese patients with hepatitis B e antigen (HBeAg) negative HBV infection and its relation to serum HBV pre-S1 antigen. The overall prevalence of the precore G1896A mutation was 72.6% in HBeAg-negative Chinese patients with detectable serum HBV DNA. The prevalence of the precore G1896A is significantly higher in Chinese HBeAg-negative patients with chronic hepatitis B than that in inactive HBV carriers with detectable serum HBV DNA. Serum pre-S1 and the precore G1896A mutation were simultaneously detected in most of Chinese HBeAg-negative patients.
format Online
Article
Text
id pubmed-3768560
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Sociedade Brasileira de Microbiologia
record_format MEDLINE/PubMed
spelling pubmed-37685602013-09-12 Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen Zhang, Jing Xu, Wei-Jia Wang, Qing Zhang, Yong Shi, Ming Braz J Microbiol Medical Microbiology This study investigated the prevalence of the precore G1896A mutation in Chinese patients with hepatitis B e antigen (HBeAg) negative HBV infection and its relation to serum HBV pre-S1 antigen. The overall prevalence of the precore G1896A mutation was 72.6% in HBeAg-negative Chinese patients with detectable serum HBV DNA. The prevalence of the precore G1896A is significantly higher in Chinese HBeAg-negative patients with chronic hepatitis B than that in inactive HBV carriers with detectable serum HBV DNA. Serum pre-S1 and the precore G1896A mutation were simultaneously detected in most of Chinese HBeAg-negative patients. Sociedade Brasileira de Microbiologia 2009 2009-12-01 /pmc/articles/PMC3768560/ /pubmed/24031448 http://dx.doi.org/10.1590/S1517-838220090004000031 Text en © Sociedade Brasileira de Microbiologia http://creativecommons.org/licenses/by-nc/3.0/ All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License
spellingShingle Medical Microbiology
Zhang, Jing
Xu, Wei-Jia
Wang, Qing
Zhang, Yong
Shi, Ming
Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen
title Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen
title_full Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen
title_fullStr Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen
title_full_unstemmed Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen
title_short Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen
title_sort prevalence of the precore g1896a mutation in chinese patients with e antigen negative hepatitis b virus infection and its relationship to pre-s1 antigen
topic Medical Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768560/
https://www.ncbi.nlm.nih.gov/pubmed/24031448
http://dx.doi.org/10.1590/S1517-838220090004000031
work_keys_str_mv AT zhangjing prevalenceoftheprecoreg1896amutationinchinesepatientswitheantigennegativehepatitisbvirusinfectionanditsrelationshiptopres1antigen
AT xuweijia prevalenceoftheprecoreg1896amutationinchinesepatientswitheantigennegativehepatitisbvirusinfectionanditsrelationshiptopres1antigen
AT wangqing prevalenceoftheprecoreg1896amutationinchinesepatientswitheantigennegativehepatitisbvirusinfectionanditsrelationshiptopres1antigen
AT zhangyong prevalenceoftheprecoreg1896amutationinchinesepatientswitheantigennegativehepatitisbvirusinfectionanditsrelationshiptopres1antigen
AT shiming prevalenceoftheprecoreg1896amutationinchinesepatientswitheantigennegativehepatitisbvirusinfectionanditsrelationshiptopres1antigen

Ejemplares similares