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Human Papillomavirus Infection in Women from Tlaxcala, Mexico

Cervical cancer is an important health problem in women living in developing countries. Infection with some genotypes of human papillomavirus (HPV) is the most important risk factor associated with cervical cancer. Little information exists about HPV genotype distribution in rural and suburban regio...

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Autores principales: Velázquez-Márquez, Noé, Jaime Jiménez-Aranda, Lucio, Sánchez-Alonso, Patricia, Santos-López, Gerardo, Reyes-Leyva, Julio, Vallejo-Ruiz, Verónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768634/
https://www.ncbi.nlm.nih.gov/pubmed/24031552
http://dx.doi.org/10.1590/S1517-83822010000300027
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author Velázquez-Márquez, Noé
Jaime Jiménez-Aranda, Lucio
Sánchez-Alonso, Patricia
Santos-López, Gerardo
Reyes-Leyva, Julio
Vallejo-Ruiz, Verónica
author_facet Velázquez-Márquez, Noé
Jaime Jiménez-Aranda, Lucio
Sánchez-Alonso, Patricia
Santos-López, Gerardo
Reyes-Leyva, Julio
Vallejo-Ruiz, Verónica
author_sort Velázquez-Márquez, Noé
collection PubMed
description Cervical cancer is an important health problem in women living in developing countries. Infection with some genotypes of human papillomavirus (HPV) is the most important risk factor associated with cervical cancer. Little information exists about HPV genotype distribution in rural and suburban regions of Mexico. Thus, we determined the prevalence of HPV genotypes in women from Tlaxcala, one of the poorest states in central Mexico, and we evaluated age infection prevalence and risk factors associated with cervical neoplasm. A cross-sectional study was conducted in 236 women seeking gynecological care at the Mexican Institute for Social Security in Tlaxcala, Mexico. Cervical scrapings were diagnosed as normal, low-grade, and high-grade squamous intraepithelial lesions (LGSIL, HGSIL). Parallel samples were used to detect HPV genotypes by PCR assays using type-specific primers for HPV 6, 11, 16, 18, and 31. An epidemiological questionnaire was applied. Prevalence of HPV infection was 31.3%. From the infected samples, prevalence of HPV 16 was 45.9%; HPV 18, 31.1%; HPV 31, 16.2%; HPV 6, 10.8%; HPV 11, 6.7%. With regard to age, the highest HPV prevalence (43.5%) was found in the 18- to 24-year-old group and the lowest (19%) in the 45- to 54-year-old group. None of the risk factors showed association with cervical neoplasia grade. HPV 16 was the most common in cervical lesions. HPV was present in 22% of normal samples and, of these, 82.6% represented high-risk HPVs. Tlaxcala showed HPV prevalence comparable to that of the largest cities in Mexico, with higher prevalence for HPV 31.
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spelling pubmed-37686342013-09-12 Human Papillomavirus Infection in Women from Tlaxcala, Mexico Velázquez-Márquez, Noé Jaime Jiménez-Aranda, Lucio Sánchez-Alonso, Patricia Santos-López, Gerardo Reyes-Leyva, Julio Vallejo-Ruiz, Verónica Braz J Microbiol Genetics and Molecular Microbiology Cervical cancer is an important health problem in women living in developing countries. Infection with some genotypes of human papillomavirus (HPV) is the most important risk factor associated with cervical cancer. Little information exists about HPV genotype distribution in rural and suburban regions of Mexico. Thus, we determined the prevalence of HPV genotypes in women from Tlaxcala, one of the poorest states in central Mexico, and we evaluated age infection prevalence and risk factors associated with cervical neoplasm. A cross-sectional study was conducted in 236 women seeking gynecological care at the Mexican Institute for Social Security in Tlaxcala, Mexico. Cervical scrapings were diagnosed as normal, low-grade, and high-grade squamous intraepithelial lesions (LGSIL, HGSIL). Parallel samples were used to detect HPV genotypes by PCR assays using type-specific primers for HPV 6, 11, 16, 18, and 31. An epidemiological questionnaire was applied. Prevalence of HPV infection was 31.3%. From the infected samples, prevalence of HPV 16 was 45.9%; HPV 18, 31.1%; HPV 31, 16.2%; HPV 6, 10.8%; HPV 11, 6.7%. With regard to age, the highest HPV prevalence (43.5%) was found in the 18- to 24-year-old group and the lowest (19%) in the 45- to 54-year-old group. None of the risk factors showed association with cervical neoplasia grade. HPV 16 was the most common in cervical lesions. HPV was present in 22% of normal samples and, of these, 82.6% represented high-risk HPVs. Tlaxcala showed HPV prevalence comparable to that of the largest cities in Mexico, with higher prevalence for HPV 31. Sociedade Brasileira de Microbiologia 2010 2010-09-01 /pmc/articles/PMC3768634/ /pubmed/24031552 http://dx.doi.org/10.1590/S1517-83822010000300027 Text en © Sociedade Brasileira de Microbiologia http://creativecommons.org/licenses/by-nc/3.0/ All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License
spellingShingle Genetics and Molecular Microbiology
Velázquez-Márquez, Noé
Jaime Jiménez-Aranda, Lucio
Sánchez-Alonso, Patricia
Santos-López, Gerardo
Reyes-Leyva, Julio
Vallejo-Ruiz, Verónica
Human Papillomavirus Infection in Women from Tlaxcala, Mexico
title Human Papillomavirus Infection in Women from Tlaxcala, Mexico
title_full Human Papillomavirus Infection in Women from Tlaxcala, Mexico
title_fullStr Human Papillomavirus Infection in Women from Tlaxcala, Mexico
title_full_unstemmed Human Papillomavirus Infection in Women from Tlaxcala, Mexico
title_short Human Papillomavirus Infection in Women from Tlaxcala, Mexico
title_sort human papillomavirus infection in women from tlaxcala, mexico
topic Genetics and Molecular Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768634/
https://www.ncbi.nlm.nih.gov/pubmed/24031552
http://dx.doi.org/10.1590/S1517-83822010000300027
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