Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine

The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in...

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Detalles Bibliográficos
Autores principales: Matos, Denise Cristina Souza, Marcovistz, Rugimar, da Silva, Andréa Marques Vieira, Quintilio, Wagner, Georgini, Ricardo Amaral
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2012
Materias:
Industrial Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768833/
https://www.ncbi.nlm.nih.gov/pubmed/24031848
http://dx.doi.org/10.1590/S1517-83822012000200001
Descripción
Sumario:The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibility and accuracy for potency pertussis control and this approach has been considered promising for use at least during the steps of production.

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