Diphtheria Antibodies and T lymphocyte Counts in Patients Infected With HIV-1

We assessed the IgG levels anti-diphtheria (D-Ab) and T cell counts (CD4+ and CD8+) in HIV-1 infected subjects undergoing or not highly active antiretroviral therapy (HAART). Approximately 70% of all HIV-1 patients were unprotected against diphtheria. There were no differences in D-Ab according to C...

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Detalles Bibliográficos
Autores principales: Speranza, Francisco A. B., Ishii, Solange K., Thuler, Luiz C. S., Damasco, Paulo V., Jr, Raphael Hirata, Mattos-Guaraldi, Ana L., Milagres, Lucimar G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2012
Materias:
Medical Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768853/
https://www.ncbi.nlm.nih.gov/pubmed/24031911
http://dx.doi.org/10.1590/S1517-838220120003000014
Descripción
Sumario:We assessed the IgG levels anti-diphtheria (D-Ab) and T cell counts (CD4+ and CD8+) in HIV-1 infected subjects undergoing or not highly active antiretroviral therapy (HAART). Approximately 70% of all HIV-1 patients were unprotected against diphtheria. There were no differences in D-Ab according to CD4 counts. Untreated patients had higher D-Ab (geometric mean of 0.62 IU/ml) than HAART-patients (geometric mean of 0.39 IU/ml). The data indicated the necessity of keeping all HIV-1 patients up-to-date with their vaccination.

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