Cargando…

Pseudorabies virus can be classified into five genotypes using partial sequences of UL44

Suid herpesvirus 1 (SuHV-1) is the causative agent of pseudorabies (PR), a disease of great importance due to the huge losses it causes in the swine industry. The aim of this study was to determine a method for genotyping SuHV-1 based on partial sequences of the gene coding for glycoprotein C (gC) a...

Descripción completa

Detalles Bibliográficos
Autores principales: Fonseca Jr., A. A., Camargos, M. F., Sales, M. L., Heinemann, M. B., Leite, R.C., Reis, J. K. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769038/
https://www.ncbi.nlm.nih.gov/pubmed/24031995
http://dx.doi.org/10.1590/S1517-838220120004000048
_version_ 1782283926987866112
author Fonseca Jr., A. A.
Camargos, M. F.
Sales, M. L.
Heinemann, M. B.
Leite, R.C.
Reis, J. K. P.
author_facet Fonseca Jr., A. A.
Camargos, M. F.
Sales, M. L.
Heinemann, M. B.
Leite, R.C.
Reis, J. K. P.
author_sort Fonseca Jr., A. A.
collection PubMed
description Suid herpesvirus 1 (SuHV-1) is the causative agent of pseudorabies (PR), a disease of great importance due to the huge losses it causes in the swine industry. The aim of this study was to determine a method for genotyping SuHV-1 based on partial sequences of the gene coding for glycoprotein C (gC) and to elucidate the possible reasons for the variability of this region. A total of 109 gCsequences collected from GenBank were divided into five major groups after reconstruction of a phylogenetic tree by Bayesian inference. The analysis showed that a portion of gC (approximately 671 bp) is under selective pressure at various points that coincide with regions of protein disorder. It was also possible to divide SuHV-1 into five genotypes that evolved under different selective pressures. These genotypes are not specific to countries or continents, perhaps due to multiple introduction events related to the importation of swine.
format Online
Article
Text
id pubmed-3769038
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Sociedade Brasileira de Microbiologia
record_format MEDLINE/PubMed
spelling pubmed-37690382013-09-12 Pseudorabies virus can be classified into five genotypes using partial sequences of UL44 Fonseca Jr., A. A. Camargos, M. F. Sales, M. L. Heinemann, M. B. Leite, R.C. Reis, J. K. P. Braz J Microbiol Genetics and Molecular Microbiology Suid herpesvirus 1 (SuHV-1) is the causative agent of pseudorabies (PR), a disease of great importance due to the huge losses it causes in the swine industry. The aim of this study was to determine a method for genotyping SuHV-1 based on partial sequences of the gene coding for glycoprotein C (gC) and to elucidate the possible reasons for the variability of this region. A total of 109 gCsequences collected from GenBank were divided into five major groups after reconstruction of a phylogenetic tree by Bayesian inference. The analysis showed that a portion of gC (approximately 671 bp) is under selective pressure at various points that coincide with regions of protein disorder. It was also possible to divide SuHV-1 into five genotypes that evolved under different selective pressures. These genotypes are not specific to countries or continents, perhaps due to multiple introduction events related to the importation of swine. Sociedade Brasileira de Microbiologia 2012 2012-06-01 /pmc/articles/PMC3769038/ /pubmed/24031995 http://dx.doi.org/10.1590/S1517-838220120004000048 Text en © Sociedade Brasileira de Microbiologia http://creativecommons.org/licenses/by-nc/3.0/ All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License
spellingShingle Genetics and Molecular Microbiology
Fonseca Jr., A. A.
Camargos, M. F.
Sales, M. L.
Heinemann, M. B.
Leite, R.C.
Reis, J. K. P.
Pseudorabies virus can be classified into five genotypes using partial sequences of UL44
title Pseudorabies virus can be classified into five genotypes using partial sequences of UL44
title_full Pseudorabies virus can be classified into five genotypes using partial sequences of UL44
title_fullStr Pseudorabies virus can be classified into five genotypes using partial sequences of UL44
title_full_unstemmed Pseudorabies virus can be classified into five genotypes using partial sequences of UL44
title_short Pseudorabies virus can be classified into five genotypes using partial sequences of UL44
title_sort pseudorabies virus can be classified into five genotypes using partial sequences of ul44
topic Genetics and Molecular Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769038/
https://www.ncbi.nlm.nih.gov/pubmed/24031995
http://dx.doi.org/10.1590/S1517-838220120004000048
work_keys_str_mv AT fonsecajraa pseudorabiesviruscanbeclassifiedintofivegenotypesusingpartialsequencesoful44
AT camargosmf pseudorabiesviruscanbeclassifiedintofivegenotypesusingpartialsequencesoful44
AT salesml pseudorabiesviruscanbeclassifiedintofivegenotypesusingpartialsequencesoful44
AT heinemannmb pseudorabiesviruscanbeclassifiedintofivegenotypesusingpartialsequencesoful44
AT leiterc pseudorabiesviruscanbeclassifiedintofivegenotypesusingpartialsequencesoful44
AT reisjkp pseudorabiesviruscanbeclassifiedintofivegenotypesusingpartialsequencesoful44