Cargando…

Prion Protein Accumulation in Lipid Rafts of Mouse Aging Brain

The cellular form of the prion protein (PrP(C)) is a normal constituent of neuronal cell membranes. The protein misfolding causes rare neurodegenerative disorders known as transmissible spongiform encephalopathies or prion diseases. These maladies can be sporadic, genetic or infectious. Sporadic pri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Agostini, Federica, Dotti, Carlos G., Pérez-Cañamás, Azucena, Ledesma, Maria Dolores, Benetti, Federico, Legname, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769255/ https://www.ncbi.nlm.nih.gov/pubmed/24040215 http://dx.doi.org/10.1371/journal.pone.0074244

Ejemplares similares

De novo prions
por: Benetti, Federico, et al.
Publicado: (2010)

New insights into structural determinants of prion protein folding and stability
por: Benetti, Federico, et al.
Publicado: (2015)

In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution
por: Gasperini, Lisa, et al.
Publicado: (2016)

Prion Protein and Copper Cooperatively Protect Neurons by Modulating NMDA Receptor Through S-nitrosylation
por: Gasperini, Lisa, et al.
Publicado: (2015)

Copper coordination modulates prion conversion and infectivity in mammalian prion proteins
por: Legname, Giuseppe
Publicado: (2023)

Pathologic Prion Protein Infects Cells by Lipid-Raft Dependent Macropinocytosis
por: Wadia, Jehangir S., et al.
Publicado: (2008)

Role of Lipid Rafts and GM1 in the Segregation and Processing of Prion Protein
por: Botto, Laura, et al.
Publicado: (2014)

Elucidating the function of the prion protein
por: Legname, Giuseppe
Publicado: (2017)

Mapping the Prion Protein Distribution in Marsupials: Insights from Comparing Opossum with Mouse CNS
por: Poggiolini, Ilaria, et al.
Publicado: (2012)

Prion protein and aging
por: Gasperini, Lisa, et al.
Publicado: (2014)

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion
por: Giachin, Gabriele, et al.
Publicado: (2015)

NMR Structure of the Human Prion Protein with the Pathological Q212P Mutation Reveals Unique Structural Features
por: Ilc, Gregor, et al.
Publicado: (2010)

Lipid‐induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders
por: Gabandé‐Rodríguez, Enrique, et al.
Publicado: (2018)

Lipid dynamics at dendritic spines
por: Dotti, Carlos Gerardo, et al.
Publicado: (2014)

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration
por: Scialò, Carlo, et al.
Publicado: (2019)

Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism
por: Takahashi, Hideyuki, et al.
Publicado: (2023)

Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation
por: Taylor, David R., et al.
Publicado: (2009)

Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease
por: Watt, Nicole T., et al.
Publicado: (2014)

Prion Protein in Stem Cells: A Lipid Raft Component Involved in the Cellular Differentiation Process
por: Martellucci, Stefano, et al.
Publicado: (2020)

Structural Consequences of Copper Binding to the Prion Protein
por: Salzano, Giulia, et al.
Publicado: (2019)

Protease-Sensitive Synthetic Prions
por: Colby, David W., et al.
Publicado: (2010)

Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1
por: Rushworth, Jo V., et al.
Publicado: (2013)

On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases
por: Legname, Giuseppe, et al.
Publicado: (2020)

Prion Protein-Specific Antibodies-Development, Modes of Action and Therapeutics Application
por: Rovis, Tihana Lenac, et al.
Publicado: (2014)

RaftProt: mammalian lipid raft proteome database
por: Shah, Anup, et al.
Publicado: (2014)

In vitro aggregation assays for the characterization of α-synuclein prion-like properties
por: Narkiewicz, Joanna, et al.
Publicado: (2014)

Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids
por: Bistaffa, Edoardo, et al.
Publicado: (2019)

Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain
por: Bradford, Barry M., et al.
Publicado: (2022)

Quantitative Profiling of Brain Lipid Raft Proteome in a Mouse Model of Fragile X Syndrome
por: Kalinowska, Magdalena, et al.
Publicado: (2015)

Investigating the Conformational Stability of Prion Strains through a Kinetic Replication Model
por: Zampieri, Mattia, et al.
Publicado: (2009)

The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells
por: Didonna, Alessandro, et al.
Publicado: (2012)

Large-scale lipidomic profiling identifies novel potential biomarkers for prion diseases and highlights lipid raft-related pathways
por: Kim, Yong-Chan, et al.
Publicado: (2021)

Lipid raft idea is floated
por: Powell, Kendall
Publicado: (2006)

Lipid rafts get connected
por: Leslie, Mitch
Publicado: (2009)

A lifeline for lipid rafts?
por: Leslie, Mitch
Publicado: (2013)

Lipid Rafts and Plant Gravisensitivity
por: Kordyum, Elizabeth L., et al.
Publicado: (2022)

PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice
por: Bistaffa, Edoardo, et al.
Publicado: (2021)

Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59(fyn) and to enhance neurite outgrowth
por: Santuccione, Antonella, et al.
Publicado: (2005)

Cholesterol-Rich Lipid Rafts as Platforms for SARS-CoV-2 Entry
por: Palacios-Rápalo, Selvin Noé, et al.
Publicado: (2021)

Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy
por: Giachin, Gabriele, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_shnk6ghua9ggqguj4muu5f799m