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Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster
Dietary restriction (DR) can result in lifespan-extension and improved function and health during ageing. Although the impact of DR on lifespan and health has been established in a variety of organisms, most DR experiments are carried out on laboratory strains that have often undergone adaptation to...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769260/ https://www.ncbi.nlm.nih.gov/pubmed/24040317 http://dx.doi.org/10.1371/journal.pone.0074681 |
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author | Metaxakis, Athanasios Partridge, Linda |
author_facet | Metaxakis, Athanasios Partridge, Linda |
author_sort | Metaxakis, Athanasios |
collection | PubMed |
description | Dietary restriction (DR) can result in lifespan-extension and improved function and health during ageing. Although the impact of DR on lifespan and health has been established in a variety of organisms, most DR experiments are carried out on laboratory strains that have often undergone adaptation to laboratory conditions. The effect of DR on animals recently derived from wild populations is rarely assessed. We measured the DR response of four populations of Drosophila melanogaster within two generations of collection from the wild. All populations responded to DR with an increase in lifespan and a decrease in female fecundity, similarly to a control, laboratory-adapted strain. These effects of DR are thus not a result of adaptation to laboratory conditions, and reflect the characteristics of natural populations. |
format | Online Article Text |
id | pubmed-3769260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37692602013-09-13 Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster Metaxakis, Athanasios Partridge, Linda PLoS One Research Article Dietary restriction (DR) can result in lifespan-extension and improved function and health during ageing. Although the impact of DR on lifespan and health has been established in a variety of organisms, most DR experiments are carried out on laboratory strains that have often undergone adaptation to laboratory conditions. The effect of DR on animals recently derived from wild populations is rarely assessed. We measured the DR response of four populations of Drosophila melanogaster within two generations of collection from the wild. All populations responded to DR with an increase in lifespan and a decrease in female fecundity, similarly to a control, laboratory-adapted strain. These effects of DR are thus not a result of adaptation to laboratory conditions, and reflect the characteristics of natural populations. Public Library of Science 2013-09-10 /pmc/articles/PMC3769260/ /pubmed/24040317 http://dx.doi.org/10.1371/journal.pone.0074681 Text en © 2013 Metaxakis, Partridge http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Metaxakis, Athanasios Partridge, Linda Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster |
title | Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster
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title_full | Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster
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title_fullStr | Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster
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title_full_unstemmed | Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster
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title_short | Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster
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title_sort | dietary restriction extends lifespan in wild-derived populations of drosophila melanogaster |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769260/ https://www.ncbi.nlm.nih.gov/pubmed/24040317 http://dx.doi.org/10.1371/journal.pone.0074681 |
work_keys_str_mv | AT metaxakisathanasios dietaryrestrictionextendslifespaninwildderivedpopulationsofdrosophilamelanogaster AT partridgelinda dietaryrestrictionextendslifespaninwildderivedpopulationsofdrosophilamelanogaster |