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Functional Analysis in Mouse Embryonic Stem Cells Reveals Wild-Type Activity for Three Msh6 Variants Found in Suspected Lynch Syndrome Patients

Lynch syndrome confers an increased risk to various types of cancer, in particular early onset colorectal and endometrial cancer. Mutations in mismatch repair (MMR) genes underlie Lynch syndrome, with the majority of mutations found in MLH1 and MSH2. Mutations in MSH6 have also been found but these...

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Detalles Bibliográficos
Autores principales:	Wielders, Eva A. L., Houlleberghs, Hellen, Isik, Gözde, te Riele, Hein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769292/ https://www.ncbi.nlm.nih.gov/pubmed/24040339 http://dx.doi.org/10.1371/journal.pone.0074766

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