The Contribution of Orai(CRACM)1 and Orai(CRACM)2 Channels in Store-Operated Ca(2+) Entry and Mediator Release in Human Lung Mast Cells

BACKGROUND: The influx of extracellular Ca(2+) into mast cells is critical for the FcεR1-dependent release of preformed granule-derived mediators and newly synthesised autacoids and cytokines. The Orai(CRACM) ion channel family provide the major pathway through which this Ca(2+) influx occurs. Howev...

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Detalles Bibliográficos
Autores principales: Ashmole, Ian, Duffy, S. Mark, Leyland, Mark L., Bradding, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769304/
https://www.ncbi.nlm.nih.gov/pubmed/24040356
http://dx.doi.org/10.1371/journal.pone.0074895

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