Impaired Cardiac SIRT1 Activity by Carbonyl Stress Contributes to Aging-Related Ischemic Intolerance

Reactive aldehydes can initiate protein oxidative damage which may contribute to heart senescence. Sirtuin 1 (SIRT1) is considered to be a potential interventional target for I/R injury management in the elderly. We hypothesized that aldehyde mediated carbonyl stress increases susceptibility of aged...

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Detalles Bibliográficos
Autores principales: Gu, Chunhu, Xing, Yuan, Jiang, Li, Chen, Mai, Xu, Ming, Yin, Yue, Li, Chen, Yang, Zheng, Yu, Lu, Ma, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769351/
https://www.ncbi.nlm.nih.gov/pubmed/24040162
http://dx.doi.org/10.1371/journal.pone.0074050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769351/
https://www.ncbi.nlm.nih.gov/pubmed/24040162
http://dx.doi.org/10.1371/journal.pone.0074050

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