Cargando…

Impaired Cardiac SIRT1 Activity by Carbonyl Stress Contributes to Aging-Related Ischemic Intolerance

Reactive aldehydes can initiate protein oxidative damage which may contribute to heart senescence. Sirtuin 1 (SIRT1) is considered to be a potential interventional target for I/R injury management in the elderly. We hypothesized that aldehyde mediated carbonyl stress increases susceptibility of aged...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Chunhu, Xing, Yuan, Jiang, Li, Chen, Mai, Xu, Ming, Yin, Yue, Li, Chen, Yang, Zheng, Yu, Lu, Ma, Heng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769351/ https://www.ncbi.nlm.nih.gov/pubmed/24040162 http://dx.doi.org/10.1371/journal.pone.0074050

Ejemplares similares

Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1
por: Wu, Bing, et al.
Publicado: (2016)

Metformin mediates cardioprotection against aging‐induced ischemic necroptosis
por: Li, Chen, et al.
Publicado: (2020)

SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury
por: Yang, Xiaoyan, et al.
Publicado: (2023)

Targeting ALDH2 for Therapeutic Interventions in Chronic Pain-Related Myocardial Ischemic Susceptibility
por: Li, Chen, et al.
Publicado: (2018)

Association of metformin monotherapy or combined therapy with cardiovascular risks in patients with type 2 diabetes mellitus
por: Li, Tian, et al.
Publicado: (2021)

SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation
por: Su, Han, et al.
Publicado: (2023)

AMPK: Potential Therapeutic Target for Ischemic Stroke
por: Jiang, Shuai, et al.
Publicado: (2018)

Clinical Observation of Extensively Hydrolysis Protein Formula With Feeding Intolerance in Preterm Infants
por: Yin, Liping, et al.
Publicado: (2022)

Loss of Sirt3 Limits Bone Marrow Cell-Mediated Angiogenesis and Cardiac Repair in Post-Myocardial Infarction
por: Zeng, Heng, et al.
Publicado: (2014)

SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice
por: Mizumoto, Tomoya, et al.
Publicado: (2022)

Ethoxycarbonylmethyl ursolate
por: Yang, Wei, et al.
Publicado: (2008)

Contribution of Peripheral Chemoreceptors to Exercise Intolerance in Heart Failure
por: Kulej-Lyko, Katarzyna, et al.
Publicado: (2022)

Reconciling Electrostatic and n→π* Orbital Contributions in Carbonyl Interactions
por: Muchowska, Kamila B., et al.
Publicado: (2020)

Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
por: Zhao, Hairong, et al.
Publicado: (2022)

Nature of Amide Carbonyl−Carbonyl Interactions in Proteins
por: Choudhary, Amit, et al.
Publicado: (2009)

Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro
por: Li, Ning, et al.
Publicado: (2018)

SIRT1 contributes to neuroendocrine differentiation of prostate cancer
por: Ruan, Lin, et al.
Publicado: (2017)

Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth
por: Xiangyun, Ye, et al.
Publicado: (2016)

New insights into Sirt1: potential therapeutic targets for the treatment of cerebral ischemic stroke
por: Tang, Hao, et al.
Publicado: (2023)

High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages
por: Terán, Graciela, et al.
Publicado: (2022)

AMPK-SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane
por: Liu, Liwei, et al.
Publicado: (2021)

Relative orientation of the carbonyl groups determines the nature of orbital interactions in carbonyl–carbonyl short contacts
por: Sahariah, Biswajit, et al.
Publicado: (2018)

Chitosan Prevents Gentamicin-Induced Nephrotoxicity via a Carbonyl Stress-Dependent Pathway
por: Chou, Chu-Kung, et al.
Publicado: (2015)

Reciprocal carbonyl–carbonyl interactions in small molecules and proteins
por: Rahim, Abdur, et al.
Publicado: (2017)

Ferroptosis contributes to hypoxic–ischemic brain injury in neonatal rats: Role of the SIRT1/Nrf2/GPx4 signaling pathway
por: Li, Chang, et al.
Publicado: (2022)

A Maternal High-Fat Diet Induces DNA Methylation Changes That Contribute to Glucose Intolerance in Offspring
por: Zhang, Qian, et al.
Publicado: (2019)

Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy
por: Wang, Weichen, et al.
Publicado: (2021)

Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of Sirt1 in hippocampus
por: Li, Xiao-Na, et al.
Publicado: (2017)

ALCAPA Presents in an Adult with Exercise Intolerance but Preserved Cardiac Function
por: Liu, Yan, et al.
Publicado: (2012)

SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo
por: Yi, Xiuli, et al.
Publicado: (2019)

Corrigendum to “Chitosan Prevents Gentamicin-Induced Nephrotoxicity via a Carbonyl Stress-Dependent Pathway”
por: Chou, Chu-Kuang, et al.
Publicado: (2017)

Dihydromyricetin Ameliorates Cardiac Ischemia/Reperfusion Injury through Sirt3 Activation
por: Wei, Liping, et al.
Publicado: (2019)

Empowering alcohols as carbonyl surrogates for Grignard-type reactions
por: Li, Chen-Chen, et al.
Publicado: (2020)

Contribution of Colonic Fermentation and Fecal Water Toxicity to the Pathophysiology of Lactose-Intolerance
por: Windey, Karen, et al.
Publicado: (2015)

α‐Thianthrenium Carbonyl Species: The Equivalent of an α‐Carbonyl Carbocation
por: Jia, Hao, et al.
Publicado: (2022)

Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations
por: Zhang, Lijie, et al.
Publicado: (2017)

SIRT3 in Cardiac Physiology and Disease
por: Koentges, Christoph, et al.
Publicado: (2016)

Regulation of microglia related neuroinflammation contributes to the protective effect of Gelsevirine on ischemic stroke
por: Xing, Chunlei, et al.
Publicado: (2023)

SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth
por: Ma, L, et al.
Publicado: (2014)

Adaptive Immune Responses Contribute to Post-ischemic Cardiac Remodeling
por: Santos-Zas, Icia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0u7kaqkqa06pl81onk3u1lgi0t