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Reduction in Cerebral Perfusion after Heroin Administration: A Resting State Arterial Spin Labeling Study

Heroin dependence is a chronic relapsing brain disorder, characterized by the compulsion to seek and use heroin. Heroin itself has a strong potential to produce subjective experiences characterized by intense euphoria, relaxation and release from craving. The neurofunctional foundations of these per...

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Autores principales: Denier, Niklaus, Gerber, Hana, Vogel, Marc, Klarhöfer, Markus, Riecher-Rossler, Anita, Wiesbeck, Gerhard A., Lang, Undine E., Borgwardt, Stefan, Walter, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769358/
https://www.ncbi.nlm.nih.gov/pubmed/24039715
http://dx.doi.org/10.1371/journal.pone.0071461
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author Denier, Niklaus
Gerber, Hana
Vogel, Marc
Klarhöfer, Markus
Riecher-Rossler, Anita
Wiesbeck, Gerhard A.
Lang, Undine E.
Borgwardt, Stefan
Walter, Marc
author_facet Denier, Niklaus
Gerber, Hana
Vogel, Marc
Klarhöfer, Markus
Riecher-Rossler, Anita
Wiesbeck, Gerhard A.
Lang, Undine E.
Borgwardt, Stefan
Walter, Marc
author_sort Denier, Niklaus
collection PubMed
description Heroin dependence is a chronic relapsing brain disorder, characterized by the compulsion to seek and use heroin. Heroin itself has a strong potential to produce subjective experiences characterized by intense euphoria, relaxation and release from craving. The neurofunctional foundations of these perceived effects are not well known. In this study, we have used pharmacological magnetic resonance imaging (phMRI) in 15 heroin-dependent patients from a stable heroin-assisted treatment program to observe the steady state effects of heroin (60 min after administration). Patients were scanned in a cross-over and placebo controlled design. They received an injection of their regular dose of heroin or saline (placebo) before or after the scan. As phMRI method, we used a pulsed arterial spin labeling (ASL) sequence based on a flow-sensitive alternating inversion recovery (FAIR) spin labeling scheme combined with a single-shot 3D GRASE (gradient-spin echo) readout on a 3 Tesla scanner. Analysis was performed with Statistical Parametric Mapping (SPM 8), using a general linear model for whole brain comparison between the heroin and placebo conditions. We found that compared to placebo, heroin was associated with reduced perfusion in the left anterior cingulate cortex (ACC), the left medial prefrontal cortex (mPFC) and in the insula (both hemispheres). Analysis of extracted perfusion values indicate strong effect sizes and no gender related differences. Reduced perfusion in these brain areas may indicate self- and emotional regulation effects of heroin in maintenance treatment.
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spelling pubmed-37693582013-09-13 Reduction in Cerebral Perfusion after Heroin Administration: A Resting State Arterial Spin Labeling Study Denier, Niklaus Gerber, Hana Vogel, Marc Klarhöfer, Markus Riecher-Rossler, Anita Wiesbeck, Gerhard A. Lang, Undine E. Borgwardt, Stefan Walter, Marc PLoS One Research Article Heroin dependence is a chronic relapsing brain disorder, characterized by the compulsion to seek and use heroin. Heroin itself has a strong potential to produce subjective experiences characterized by intense euphoria, relaxation and release from craving. The neurofunctional foundations of these perceived effects are not well known. In this study, we have used pharmacological magnetic resonance imaging (phMRI) in 15 heroin-dependent patients from a stable heroin-assisted treatment program to observe the steady state effects of heroin (60 min after administration). Patients were scanned in a cross-over and placebo controlled design. They received an injection of their regular dose of heroin or saline (placebo) before or after the scan. As phMRI method, we used a pulsed arterial spin labeling (ASL) sequence based on a flow-sensitive alternating inversion recovery (FAIR) spin labeling scheme combined with a single-shot 3D GRASE (gradient-spin echo) readout on a 3 Tesla scanner. Analysis was performed with Statistical Parametric Mapping (SPM 8), using a general linear model for whole brain comparison between the heroin and placebo conditions. We found that compared to placebo, heroin was associated with reduced perfusion in the left anterior cingulate cortex (ACC), the left medial prefrontal cortex (mPFC) and in the insula (both hemispheres). Analysis of extracted perfusion values indicate strong effect sizes and no gender related differences. Reduced perfusion in these brain areas may indicate self- and emotional regulation effects of heroin in maintenance treatment. Public Library of Science 2013-09-10 /pmc/articles/PMC3769358/ /pubmed/24039715 http://dx.doi.org/10.1371/journal.pone.0071461 Text en © 2013 Denier et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Denier, Niklaus
Gerber, Hana
Vogel, Marc
Klarhöfer, Markus
Riecher-Rossler, Anita
Wiesbeck, Gerhard A.
Lang, Undine E.
Borgwardt, Stefan
Walter, Marc
Reduction in Cerebral Perfusion after Heroin Administration: A Resting State Arterial Spin Labeling Study
title Reduction in Cerebral Perfusion after Heroin Administration: A Resting State Arterial Spin Labeling Study
title_full Reduction in Cerebral Perfusion after Heroin Administration: A Resting State Arterial Spin Labeling Study
title_fullStr Reduction in Cerebral Perfusion after Heroin Administration: A Resting State Arterial Spin Labeling Study
title_full_unstemmed Reduction in Cerebral Perfusion after Heroin Administration: A Resting State Arterial Spin Labeling Study
title_short Reduction in Cerebral Perfusion after Heroin Administration: A Resting State Arterial Spin Labeling Study
title_sort reduction in cerebral perfusion after heroin administration: a resting state arterial spin labeling study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769358/
https://www.ncbi.nlm.nih.gov/pubmed/24039715
http://dx.doi.org/10.1371/journal.pone.0071461
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