Hypoxia-Inducible Factor-1alpha and MAPK Co-Regulate Activation of Hepatic Stellate Cells upon Hypoxia Stimulation

BACKGROUND: Hepatic stellate cell (HSC) plays a key role in pathogenesis of liver fibrosis. During liver injury, hypoxia in local micro-environment is inevitable. Hif-1α is the key transcriptional regulation factor that induces cell’s adaptive responses to hypoxia. Recently, it was reported that MAP...

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Detalles Bibliográficos
Autores principales: Wang, Yueqin, Huang, Yimin, Guan, Fei, Xiao, Yan, Deng, Jing, Chen, Huoying, Chen, Xiaolin, Li, Jianrong, Huang, Hanju, Shi, Chunwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769364/
https://www.ncbi.nlm.nih.gov/pubmed/24040163
http://dx.doi.org/10.1371/journal.pone.0074051

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