Quercetin Inhibits Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats and Inhibits Angiotensin II-Induced H9C2 Cells Hypertrophy by Enhancing PPAR-γ Expression and Suppressing AP-1 Activity

BACKGROUND: Quercetin is the most abundant flavonoid in fruit and vegetables and is believed to attenuate cardiovascular disease. We hypothesized that quercetin inhibits cardiac hypertrophy by blocking AP-1 (c-fos, c-jun) and activating PPAR-γ signaling pathways. METHODOLOGY/PRINCIPAL FINDINGS: The...

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Detalles Bibliográficos
Autores principales: Yan, Lei, Zhang, Ji Dong, Wang, Bo, Lv, Yi Jing, Jiang, Hong, Liu, Gui Lin, Qiao, Yun, Ren, Ming, Guo, Xue Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769399/
https://www.ncbi.nlm.nih.gov/pubmed/24039778
http://dx.doi.org/10.1371/journal.pone.0072548

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