Relative Biological Effectiveness (RBE) of (131)I Radiation Relative to (60)Co Gamma Rays

OBJECTIVE: To assess relative biological effectiveness (RBE) of (131)I radiation relative to (60)Co gamma rays in glioblastoma spheroid cells. MATERIALS AND METHODS: : In this experimental study, glioblastoma spheroid cells were exposed to (131)I radiation and (60)Co gamma rays. Radiation induced DN...

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Autores principales: Neshasteh-Riz, Ali, Mahmoud Pashazadeh, Ali, Mahdavi, Seyed Rabie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769604/
https://www.ncbi.nlm.nih.gov/pubmed/24027663
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author Neshasteh-Riz, Ali
Mahmoud Pashazadeh, Ali
Mahdavi, Seyed Rabie
author_facet Neshasteh-Riz, Ali
Mahmoud Pashazadeh, Ali
Mahdavi, Seyed Rabie
author_sort Neshasteh-Riz, Ali
collection PubMed
description OBJECTIVE: To assess relative biological effectiveness (RBE) of (131)I radiation relative to (60)Co gamma rays in glioblastoma spheroid cells. MATERIALS AND METHODS: : In this experimental study, glioblastoma spheroid cells were exposed to (131)I radiation and (60)Co gamma rays. Radiation induced DNA damage was evaluated by alkaline comet assay. Samples of spheroid cells were treated by radiation from (131)I for four different periods of time to find the dose-response equation. Spheroid cells were also exposed by 200 cGy of (60)Co gamma rays as reference radiation to induce DNA damage as endpoint. RESULTS: Resulted RBE of (131)I radiation relative to (60)Co gamma rays in 100 µm giloblastoma spheroid cells was equal to 1.16. CONCLUSION: The finding of this study suggests that (131)I photons and electrons can be more effective than (60)Co gamma rays to produce DNA damage in glioblastoma spheroid cells.
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spelling pubmed-37696042013-09-11 Relative Biological Effectiveness (RBE) of (131)I Radiation Relative to (60)Co Gamma Rays Neshasteh-Riz, Ali Mahmoud Pashazadeh, Ali Mahdavi, Seyed Rabie Cell J Research Article OBJECTIVE: To assess relative biological effectiveness (RBE) of (131)I radiation relative to (60)Co gamma rays in glioblastoma spheroid cells. MATERIALS AND METHODS: : In this experimental study, glioblastoma spheroid cells were exposed to (131)I radiation and (60)Co gamma rays. Radiation induced DNA damage was evaluated by alkaline comet assay. Samples of spheroid cells were treated by radiation from (131)I for four different periods of time to find the dose-response equation. Spheroid cells were also exposed by 200 cGy of (60)Co gamma rays as reference radiation to induce DNA damage as endpoint. RESULTS: Resulted RBE of (131)I radiation relative to (60)Co gamma rays in 100 µm giloblastoma spheroid cells was equal to 1.16. CONCLUSION: The finding of this study suggests that (131)I photons and electrons can be more effective than (60)Co gamma rays to produce DNA damage in glioblastoma spheroid cells. Royan Institute 2013 2013-08-24 /pmc/articles/PMC3769604/ /pubmed/24027663 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Neshasteh-Riz, Ali
Mahmoud Pashazadeh, Ali
Mahdavi, Seyed Rabie
Relative Biological Effectiveness (RBE) of (131)I Radiation Relative to (60)Co Gamma Rays
title Relative Biological Effectiveness (RBE) of (131)I Radiation Relative to (60)Co Gamma Rays
title_full Relative Biological Effectiveness (RBE) of (131)I Radiation Relative to (60)Co Gamma Rays
title_fullStr Relative Biological Effectiveness (RBE) of (131)I Radiation Relative to (60)Co Gamma Rays
title_full_unstemmed Relative Biological Effectiveness (RBE) of (131)I Radiation Relative to (60)Co Gamma Rays
title_short Relative Biological Effectiveness (RBE) of (131)I Radiation Relative to (60)Co Gamma Rays
title_sort relative biological effectiveness (rbe) of (131)i radiation relative to (60)co gamma rays
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769604/
https://www.ncbi.nlm.nih.gov/pubmed/24027663
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