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Structural and Functional Analysis of Giant Strong Component of Bacillus thuringiensis Metabolic Network

The purpose of this work was to study the giant strong component (GSC) of B. thuringiensis metabolic network by structural and functional analysis. Based on so-called “bow tie” structure, we extracted and studied GSC with its functional significance. Global structural properties such as degree distr...

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Detalles Bibliográficos
Autores principales: Ding, D.W., Ding, Y.R., Li, L.N., Cai, Y.J., Xu, W.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769732/
https://www.ncbi.nlm.nih.gov/pubmed/24031381
http://dx.doi.org/10.1590/S1517-838220090002000036
Descripción
Sumario:The purpose of this work was to study the giant strong component (GSC) of B. thuringiensis metabolic network by structural and functional analysis. Based on so-called “bow tie” structure, we extracted and studied GSC with its functional significance. Global structural properties such as degree distribution and average path length were computed and indicated that the GSC is also a small-world and scale-free network. Furthermore, the GSC was decomposed and functional significant for metabolism of these divisions were investigated by comparing to KEGG metabolic pathways.